IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2003;44:1150-1154.)
© 2003 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.02-0541
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dong, X.
Right arrow Articles by Söderberg, P. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dong, X.
Right arrow Articles by Söderberg, P. G.

Ultraviolet Radiation–Induced Cataract: Age and Maximum Acceptable Dose

Xiuqin Dong, Marcelo Ayala, Stefan Löfgren, and Per G. Söderberg

From the St. Erik’s Eye Hospital, Karolinska Institute, Stockholm, Sweden.

PURPOSE. To investigate the effect of age on ultraviolet radiation-B (UVR-B)–induced cataract and to detect the maximum acceptable dose in rats of different age groups.

METHODS. Four age groups of 20 rats each, aged 3, 6, 10, and 18 weeks, were included. Each age group was divided into five UVR-B dose subgroups. The rats were unilaterally exposed to UVR-B ({lambda}max = 302.6 nm, {lambda}0.5 = 4.5 nm). The incident dose on the cornea varied between 0 and 8 kJ/m2. One week after exposure, the rats were killed, both lenses were extracted, the intensity of forward light-scattering was measured, and photographs were taken. The sensitivity of the lens to UVR-B was estimated as the maximum acceptable dose.

RESULTS. The maximum acceptable dose for 3-, 6-, 10-, and 18-week-old rats was estimated to be 1.4, 2.7, 4.3 and 5.2 kJ/m2, respectively.

CONCLUSIONS. Young rats were more sensitive to UVR-B than old ones. Age should be considered when estimating the risk for UVR-B–induced cataract.




This article has been cited by other articles:


Home page
 IOVSHome page
P. Raju, S. Ve Ramesh, H. Arvind, R. George, M. Baskaran, P. G. Paul, G. Kumaramanickavel, C. McCarty, and L. Vijaya
Prevalence of Refractive Errors in a Rural South Indian Population
Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4268 - 4272.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Association for Research in Vision and Ophthalmology