| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1From the Hamilton Glaucoma Center and Department of Ophthalmology and the 2Department of Psychiatry, University of California, San Diego, La Jolla, California.
PURPOSE. To characterize the 24-hour pattern of intraocular pressure (IOP) in untreated patients with newly diagnosed early glaucomatous changes.
METHODS. Measurements of IOP, blood pressure, and heart rate were taken every 2 hours during a 24-hour period from a group of 24 untreated patients (ages 40–78 years) with newly diagnosed abnormal optic discs and/or abnormal visual fields. In the 16-hour diurnal awake period, IOP was measured sitting and supine, and blood pressure and heart rate were measured supine. In the 8-hour nocturnal sleep period, all measurements were taken in the supine position. Mean diurnal and nocturnal IOP, blood pressure, and heart rate in the glaucoma group were compared with data obtained from an age-matched control group of 24 individuals with healthy eyes.
RESULTS. Mean diurnal IOP, either sitting or supine, was significantly higher in the glaucoma group than in the control group. For both subject groups, nocturnal supine IOP was higher than diurnal sitting IOP. However, this diurnal-to-nocturnal increase in IOP was significantly smaller in the glaucoma group. When compared with the diurnal supine IOP, the nocturnal supine IOP was lower in the glaucoma group but higher in the control group. Around normal awakening time, the supine IOP increased in the glaucoma group and did not change in the control group. There was a diurnal-to-nocturnal decrease in mean blood pressure only in the glaucoma group.
CONCLUSIONS. Compared with healthy eyes, the diurnal IOP is higher, the diurnal-to-nocturnal change of habitual IOP is less, and the posture-independent IOP pattern around normal awakening time is different in eyes with early glaucomatous changes.
This article has been cited by other articles:
|
|
 |
|
  S. A. Read, M. J. Collins, and D. R. Iskander Diurnal Variation of Axial Length, Intraocular Pressure, and Anterior Eye Biometrics Invest. Ophthalmol. Vis. Sci., July 1, 2008; 49(7): 2911 - 2918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Sit, C. B. Nau, J. W. McLaren, D. H. Johnson, and D. Hodge Circadian Variation of Aqueous Dynamics in Young Healthy Adults Invest. Ophthalmol. Vis. Sci., April 1, 2008; 49(4): 1473 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Mansouri, S Orguel, A Mermoud, I Haefliger, J Flammer, E Ravinet, and T Shaarawy Quality of diurnal intraocular pressure control in primary open-angle patients treated with latanoprost compared with surgically treated glaucoma patients: a prospective trial Br. J. Ophthalmol., March 1, 2008; 92(3): 332 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Ramos and W. D. Stamer Effects of Cyclic Intraocular Pressure on Conventional Outflow Facility Invest. Ophthalmol. Vis. Sci., January 1, 2008; 49(1): 275 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kida, J. H. K. Liu, and R. N. Weinreb Effect of 24-hour corneal biomechanical changes on intraocular pressure measurement. Invest. Ophthalmol. Vis. Sci., October 1, 2006; 47(10): 4422 - 4426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Barkana, S. Anis, J. Liebmann, C. Tello, and R. Ritch Clinical utility of intraocular pressure monitoring outside of normal office hours in patients with glaucoma. Arch Ophthalmol, June 1, 2006; 124(6): 793 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Choi, J. Jeong, H.-s. Cho, and M. S. Kook Effect of nocturnal blood pressure reduction on circadian fluctuation of mean ocular perfusion pressure: a risk factor for normal tension glaucoma. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 831 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Susanna Jr, M. Hatanaka, R. M. Vessani, A. Pinheiro, and C. Morita Correlation of Asymmetric Glaucomatous Visual Field Damage and Water-Drinking Test Response Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 641 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hara, T. Hara, and T. Tsuru Increase of peak intraocular pressure during sleep in reproduced diurnal changes by posture. Arch Ophthalmol, February 1, 2006; 124(2): 165 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Weinreb and J. H. K. Liu Nocturnal rhythms of intraocular pressure. Arch Ophthalmol, February 1, 2006; 124(2): 269 - 270. [Full Text] [PDF]
|
|
|
|
|
|
P Fogagnolo, L Rossetti, F Mazzolani, and N Orzalesi Circadian variations in central corneal thickness and intraocular pressure in patients with glaucoma Br. J. Ophthalmol., January 1, 2006; 90(1): 24 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sehi, J. G. Flanagan, L. Zeng, R. J. Cook, and G. E. Trope Relative Change in Diurnal Mean Ocular Perfusion Pressure: A Risk Factor for the Diagnosis of Primary Open-Angle Glaucoma Invest. Ophthalmol. Vis. Sci., February 1, 2005; 46(2): 561 - 567. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
