IOVS Learning & Memory
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2003;44:2361-2366.)
© 2003 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.02-0911
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Foster, F. S.
Right arrow Articles by Pavlin, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Foster, F. S.
Right arrow Articles by Pavlin, C. J.

In Vivo Imaging of Embryonic Development in the Mouse Eye by Ultrasound Biomicroscopy

F. Stuart Foster,1,2 MingYu Zhang,1 Allison S. Duckett,1,2 Viviene Cucevic,1 and Charles J. Pavlin3,4

1From the Sunnybrook and Women’s College Health Sciences Centre, the 2Mouse Imaging Centre at the Hospital for Sick Children, and the 3Departments of Medical Biophysics and 4Ophthalmology, University of Toronto, Toronto, Ontario, Canada.

PURPOSE. New imaging tools now provide an unprecedented opportunity to visualize anatomic and functional development of the mouse eye. In this study, normal embryonic development of the mouse eye was studied by ultrasound biomicroscopy (UBM), with a focus on the formation of the retina, lens, and cornea.

METHODS. The growth of 65 embryonic eyes from timed-pregnant CD-1 mice was examined at various stages of development between embryonic day (E)11.5 and E18.5, using 40-MHz UBM.

RESULTS. The morphogenesis of ocular tissues including the lens, retina, and orbit were revealed from the earliest stages of development. The major axis of the CD-1 lens grows at a rate of 68 µm/d, whereas that of the globe grows at a rate of 122 µm/d, with a concomitant exponential increase in volume.

CONCLUSIONS. UBM allows noninvasive assessment of ocular morphogenesis in vivo and can be used to calculate relative growth rates of ocular structures.




This article has been cited by other articles:


Home page
 J Ultrasound MedHome page
M. Soldan, A. Schanaider, K. Madi, C. Zaltman, and J. C. Machado
In Vitro Ultrasound Biomicroscopic Imaging of Colitis in Rats
J. Ultrasound Med., April 1, 2009; 28(4): 463 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Lab AnimHome page
P Pallares and A Gonzalez-Bulnes
Use of ultrasound imaging for early diagnosis of pregnancy and determination of litter size in the mouse
Lab Anim, January 1, 2009; 43(1): 91 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. R. McVeigh
Emerging Imaging Techniques
Circ. Res., April 14, 2006; 98(7): 879 - 886.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. S. Brown, L. Leamen, V. Cucevic, and F. S. Foster
Quantitation of Hemodynamic Function during Developmental Vascular Regression in the Mouse Eye
Invest. Ophthalmol. Vis. Sci., July 1, 2005; 46(7): 2231 - 2237.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Association for Research in Vision and Ophthalmology