IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2004;45:3446-3452.)
© 2004 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.03-1058
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liang, C.-L.
Right arrow Articles by Juo, S.-H. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liang, C.-L.
Right arrow Articles by Juo, S.-H. H.

Impact of Family History of High Myopia on Level and Onset of Myopia

Chung-Ling Liang,1,2 Eugene Yen,1 Jui-Yung Su,1 Chang Liu,3 Tzu-Yi Chang,1 Naeun Park,3 Ming-Jin Wu,4 Sharon Lee,3 John T. Flynn,5 and Suh-Hang Hank Juo3,6,7

1From the Department of Ophthalmology, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan; 2Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kaohsiung, Taiwan; the 3Genome Center and 5Departments of Ophthalmology and 6Epidemiology, Columbia University, New York, New York; 4Department of Biological Sciences, Sun Yat-Sen University, Kaohsiung, Taiwan; and 7Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.

PURPOSE. To investigate the impact of a positive family history of high myopia on the level and onset of myopia and its ocular components.

METHODS. A cross-sectional study was conducted. The participants (aged 17 to 45 years) were categorized into four groups: normal, mild, moderate, and high myopia. The age of first glasses for myopia was used as the onset of myopia. The impact of the family history on the level and the onset of myopia was quantified. Parental effect on corneal curvature (CC), anterior chamber depth (ACD), and axial length (AXL) was analyzed.

RESULTS. The study included 185 normal subjects, 170 mild, 140 moderate, and 392 high myopes. Family history was strongly associated with the probands’ status (P < 6 x 10-12). When there was ≥1 highly myopic parent, the odds ratios (ORs) of developing mild or moderate myopia were between 2.5 and 3.7 (95% CI: 1.1–6.5) and the ORs of having high myopia were > 5.5 (95% CI: 3.2–12.6). A strong association (P = 2 x 10-6) between parental myopic state and the AXL in the subjects was also found, but there was no statistical relationship for ACD or CC. There was an association between high myopia in parents and the onset of myopia in children. Siblings had a weaker association with the level of myopia and had no effect on the onset of myopia.

CONCLUSIONS. This study found strong familial effects on the level and onset of myopia even after adjusting for environmental factors. The parental effect on ocular components in their offspring was primarily on AXL.




This article has been cited by other articles:


Home page
 IOVSHome page
K. K. Pertile, M. Schache, F. M. A. Islam, C. Y. Chen, M. Dirani, P. Mitchell, and P. N. Baird
Assessment of TGIF as a Candidate Gene for Myopia
Invest. Ophthalmol. Vis. Sci., January 1, 2008; 49(1): 49 - 54.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. Y. Chen, J. Stankovich, K. J. Scurrah, P. Garoufalis, M. Dirani, K. K. Pertile, A. J. Richardson, and P. N. Baird
Linkage Replication of the MYP12 Locus in Common Myopia
Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4433 - 4439.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
W. Han, M. K. H. Yap, J. Wang, and S. P. Yip
Family-Based Association Analysis of Hepatocyte Growth Factor (HGF) Gene Polymorphisms in High Myopia.
Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2291 - 2299.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S.-M. Saw, A. Shankar, S.-B. Tan, H. Taylor, D. T. H. Tan, R. A. Stone, and T.-Y. Wong
A Cohort Study of Incident Myopia in Singaporean Children
Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1839 - 1844.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
S M Saw, W H Chua, G Gazzard, D Koh, D T H Tan, and R A Stone
Eye growth changes in myopic children in Singapore
Br. J. Ophthalmol., November 1, 2005; 89(11): 1489 - 1494.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Association for Research in Vision and Ophthalmology