IOVS Proceedings of the National Academy of Sciences
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2004;45:3644-3649.)
© 2004 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.04-0228
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hayden, B. C.
Right arrow Articles by Parel, J.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayden, B. C.
Right arrow Articles by Parel, J.-M.

Pharmacokinetics of Systemic Versus Focal Carboplatin Chemotherapy in the Rabbit Eye: Possible Implication in the Treatment of Retinoblastoma

Brandy C. Hayden,1 Maria-Elena Jockovich,1 Timothy G. Murray,1 Monika Voigt,1,2 Peter Milne,1,3 Martina Kralinger,1,4 William J. Feuer,1 Eleut Hernandez,1 and Jean-Marie Parel1,5

1From the Bascom Palmer Eye Institute, Department of Ophthalmology and the 3Rosenstiel Marine School, University of Miami, Miami, Florida; the 2Ophthalmic Clinic of Virchow/Charité Hospital, Humboldt University of Berlin, Berlin, Germany; the 4Ophthalmic Clinic, University of Innsbruck, Austria, Innsbruck, Austria; and the 5Department of Ophthalmology, University of Liège, Centre Universitaire Hospitalier Sart-Tilman, Liège, Belgium.

PURPOSE. To characterize the pharmacology and toxicity of intravenous versus focal carboplatin delivery in the rabbit eye.

METHODS. Pharmacological distribution of carboplatin was examined in New Zealand White Rabbits after a single intravenous infusion of carboplatin (18.7 mg/kg of body weight), a single subconjunctival carboplatin injection (5.0 mg/400 µL), or a single application of carboplatin delivered by Coulomb-controlled iontophoresis (CCI; 14 mg/mL carboplatin, 5.0 mA/cm2, 20 minutes). After each treatment, animals were euthanatized, and the eyes analyzed at 1, 2, 6, or 24 hours by atomic absorption spectroscopy to determine carboplatin concentration in ocular structures. Potential toxicity of focally delivered carboplatin was assessed by histology after six cycles of 5.0 mg carboplatin delivered by subconjunctival injection or six transscleral carboplatin CCI applications at 72-hour intervals (14.0 mg/mL, 20 minutes at 2.5 mA).

RESULTS. Determination of concentrations through atomic absorption spectroscopy in the retina, choroid, vitreous humor, and optic nerve after subconjunctival injection or iontophoretic carboplatin delivery revealed significantly higher levels than those achieved with intravenous administration. Carboplatin concentrations in the blood plasma were found to be significantly higher after intravenous delivery than after focal delivery by subconjunctival injection or CCI. No evidence of ocular toxicity was detected after focally delivered Carboplatin.

CONCLUSIONS. Focal administration of carboplatin using subconjunctival or noninvasive CCI safely and effectively transmits this chemotherapeutic drug into the target tissues of the retina, choroid, vitreous, and optic nerve. These results suggest that focal carboplatin delivery may effectively increase intraorbital carboplatin concentrations while decreasing systemic exposure to this cytotoxic drug.




This article has been cited by other articles:


Home page
 IOVSHome page
A. C. Amrite, H. F. Edelhauser, and U. B. Kompella
Modeling of Corneal and Retinal Pharmacokinetics after Periocular Drug Administration
Invest. Ophthalmol. Vis. Sci., January 1, 2008; 49(1): 320 - 332.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. M. Carcaboso, G. F. Bramuglia, G. L. Chantada, A. C. Fandino, D. A. Chiappetta, M. T. G. de Davila, M. C. Rubio, and D. H. Abramson
Topotecan Vitreous Levels after Periocular or Intravenous Delivery in Rabbits: An Alternative for Retinoblastoma Chemotherapy
Invest. Ophthalmol. Vis. Sci., August 1, 2007; 48(8): 3761 - 3767.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
A Barak, M Neudorfer, G Heilweil, O Merimsky, A Lowenstein, M Inbar, and N Yaal-Hahoshen
Decreased prevalence of asymptomatic choroidal metastasis in disseminated breast and lung cancer: argument against screening
Br. J. Ophthalmol., January 1, 2007; 91(1): 74 - 75.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
B. Hayden, M.-E. Jockovich, T. G. Murray, M. T. Kralinger, M. Voigt, E. Hernandez, W. Feuer, and J.-M. Parel
Iontophoretic delivery of Carboplatin in a murine model of retinoblastoma.
Invest. Ophthalmol. Vis. Sci., September 1, 2006; 47(9): 3717 - 3721.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M.-E. Jockovich, T. G. Murray, E. Escalona-Benz, E. Hernandez, and W. Feuer
Anecortave Acetate as Single and Adjuvant Therapy in the Treatment of Retinal Tumors of LHBETATAG Mice.
Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1264 - 1268.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Association for Research in Vision and Ophthalmology