| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1From the Schepens Eye Research Institute, Boston, Massachusetts; the 2Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin; and the 3Department of Psychology, Brown University, Providence, Rhode Island.
PURPOSE. To develop a standardized protocol for measuring macular pigment optical density (MPOD) of experimentally naïve subjects by heterochromatic flicker photometry (HFP).
METHODS. MPOD in eyes of 54 women, age 50 and 79 years (mean, 66), was studied. The spatial profile of MPOD was measured in the right eye, and two spatial points were also measured in the left eye. Forty-eight of these inexperienced subjects completed the protocol on two separate visits. For a subset of the group, the MPOD at two different wavelengths was measured.
RESULTS. The test–retest correlation at 0.5° eccentricity in the right eye was 0.9. On the second visit, more than 90% of the subjects were able to perform the HFP test with results that were consistent with the absorption spectrum of macular pigment. On the first visit, data from the inexperienced subjects deviated more from the expected relationships between the two wavelengths, presumably because they had less skill in performing the task. However, subjects with high or low macular pigment density were distinguished clearly.
CONCLUSIONS. Reliable and meaningful measurements of macular pigment density in older subjects can be made using HFP, with a standardized protocol in the limited time available in large epidemiologic studies. This protocol will be made freely available to other researchers on request.
This article has been cited by other articles:
|
|
 |
|
  L. L. Huang, H. R. Coleman, J. Kim, F. de Monasterio, W. T. Wong, R. L. Schleicher, F. L. Ferris III, and E. Y. Chew Oral Supplementation of Lutein/Zeaxanthin and Omega-3 Long Chain Polyunsaturated Fatty Acids in Persons Aged 60 Years or Older, with or without AMD Invest. Ophthalmol. Vis. Sci., September 1, 2008; 49(9): 3864 - 3869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J Johnson, H.-Y. Chung, S. M Caldarella, and D M. Snodderly The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1521 - 1529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Nolan, J. M. Stringham, S. Beatty, and D. M. Snodderly Spatial Profile of Macular Pigment and Its Relationship to Foveal Architecture Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 2134 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Moeller, R. Voland, L. Tinker, B. A. Blodi, M. L. Klein, K. M. Gehrs, E. J. Johnson, D. M. Snodderly, R. B. Wallace, R. J. Chappell, et al. Associations Between Age-Related Nuclear Cataract and Lutein and Zeaxanthin in the Diet and Serum in the Carotenoids in the Age-Related Eye Disease Study (CAREDS), an Ancillary Study of the Women's Health Initiative Arch Ophthalmol, March 1, 2008; 126(3): 354 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Iannaccone, M. Mura, K. T. Gallaher, E. J. Johnson, W. A. Todd, E. Kenyon, T. L. Harris, T. Harris, S. Satterfield, K. C. Johnson, et al. Macular Pigment Optical Density in the Elderly: Findings in a Large Biracial Midsouth Population Sample Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1458 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R E Hogg, R S Anderson, M R Stevenson, M B Zlatkova, and U Chakravarthy In vivo macular pigment measurements: a comparison of resonance Raman spectroscopy and heterochromatic flicker photometry Br. J. Ophthalmol., April 1, 2007; 91(4): 485 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Aleman, A. V. Cideciyan, E. A. M. Windsor, S. B. Schwartz, M. Swider, J. D. Chico, A. Sumaroka, A. Y. Pantelyat, K. G. Duncan, L. M. Gardner, et al. Macular Pigment and Lutein Supplementation in ABCA4-Associated Retinal Degenerations Invest. Ophthalmol. Vis. Sci., March 1, 2007; 48(3): 1319 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bhosale, D. Y. Zhao, and P. S. Bernstein HPLC Measurement of Ocular Carotenoid Levels in Human Donor Eyes in the Lutein Supplementation Era Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 543 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Rosenthal, J. Kim, F. de Monastario, D. J. S. Thompson, R. A. Bone, J. T. Landrum, F. F. de Moura, F. Khachik, H. Chen, R. L. Schleicher, et al. Dose-Ranging Study of Lutein Supplementation in Persons Aged 60 Years or Older Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5227 - 5233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Mares, T. L LaRowe, D M. Snodderly, S. M Moeller, M. J Gruber, M. L Klein, B. R Wooten, E. J Johnson, R. J Chappell, and for the CAREDS Macular Pigment Study Group and Inv Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 1107 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Whitehead, J. A. Mares, and R. P. Danis Macular Pigment: A Review of Current Knowledge Arch Ophthalmol, July 1, 2006; 124(7): 1038 - 1045. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
