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(Investigative Ophthalmology and Visual Science. 2004;45:539-545.)
© 2004 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.03-0092
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Magnetic Resonance Imaging Study of the Effects of Age and Accommodation on the Human Lens Cross-Sectional Area

Susan A. Strenk,1 Lawrence M. Strenk,2 John L. Semmlow,1,3 and J. Kevin DeMarco4

1From the Department of Surgery (Bioengineering), University of Medicine and Dentistry New Jersey (UMDNJ)-Robert Wood Johnson Medical School, New Brunswick, New Jersey; 2MRI Research, Middleburg Heights, Ohio; the 3Department of Biomedical Engineering, Rutgers-The State University of New Jersey, Piscataway, New Jersey; and the 4Laurie Imaging Center, New Brunswick, New Jersey.

PURPOSE. To evaluate the effect of age and accommodation on lens cross-sectional area (CSA).

METHODS. High-resolution magnetic resonance images of the eye were acquired from 25 subjects ranging in age from 22 to 50 years during accommodation and with accommodation at rest. The images were analyzed to obtain the total lens CSA and the CSAs of the anterior and posterior portions of the lens.

RESULTS. The total lens CSA and the CSA of the anterior portion increased with age in both accommodative states. With accommodation, the CSA was larger in these portions of the lens; however, this difference decreased with age. Conversely, the CSA of the posterior portion of the lens remained statistically independent of both age and accommodative state.

CONCLUSIONS. This preliminary study documents, in vivo, that the lens grows with age. This growth appears to be confined to the anterior portion. A quite unexpected finding is that both the total lens CSA and the CSA of the anterior portion are greater during accommodation when zonular tension is minimized. This accommodative change in CSA, which decreases with age, may be due to compression of the lens material during relaxed accommodation when zonular tension is greatest. That both age and accommodative changes in CSA appear to be limited to the anterior portion of the lens may be related to properties of the anterior capsule and lens material, the position of the zonular attachments, and the location of the fetal nucleus.




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eLetters:

Read all eLetters

The Change in Intralenticular Pressure during Human Accommodation
Ronald A. Schachar
IOVS Online, 6 May 2004 [Full text]
The MRI Data of Strenk et al. Do Not Suggest Lens Compression in the Unaccommodated State
Stuart J. Judge, et al.
IOVS Online, 6 May 2004 [Full text]
Our Findings Suggest a Compressible Lens Material and Support the Helmholtz Theory of Presbyopia
Susan A. Strenk, et al.
IOVS Online, 6 May 2004 [Full text]
Change in Intralenticular Pressure during Accommodation
Ronald A. Schachar
IOVS Online, 17 Aug 2004 [Full text]
Author Response: Change in Intralenticular Pressure during Accommodation
Susan A. Strenk
IOVS Online, 17 Aug 2004 [Full text]
Change in Intralenticular Pressure during Accommodation
Ronald A. Schachar
IOVS Online, 30 Mar 2005 [Full text]
Author Response: Change in Intralenticular Pressure during Accommodation
Susan A. Strenk
IOVS Online, 30 Mar 2005 [Full text]

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