HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (33) Citing Articles via Google Scholar Google Scholar Articles by Scholl, H. P. N. Articles by Fitzke, F. W. Search for Related Content PubMed PubMed Citation Articles by Scholl, H. P. N. Articles by Fitzke, F. W.

Photopic and Scotopic Fine Matrix Mapping of Retinal Areas of Increased Fundus Autofluorescence in Patients with Age-Related Maculopathy

From the Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom.

PURPOSE. To investigate photopic and scotopic sensitivity of retinal areas that show increased fundus autofluorescence (FAF) in patients with age-related maculopathy (ARM).

METHODS. FAF was imaged with a modified confocal scanning laser ophthalmoscope (cSLO). Fine matrix mapping (FMM) was performed with a modified field analyzer. Photopic and scotopic thresholds were obtained at 100 locations on a 9° x 9° matrix with 1° spacing, centered on a macular area of increased FAF. Inclusion criteria included ARM fundus changes, areas of increased FAF, central and stable fixation, and visual acuity of 20/40 or better.

RESULTS. FAF images were reviewed in 436 patients with age-related maculopathy (ARM), of whom 38 met the inclusion criteria. FMM was performed in seven eyes of seven patients. Areas of increased FAF in patients with late ARM (choroidal neovascularization or geographic atrophy) showed normal or only mildly abnormal photopic, but severely reduced scotopic, sensitivity. The central area of increased FAF corresponding to a large foveal druse in a patient with ARM showed moderately reduced photopic and severely reduced scotopic sensitivity. In the other patients with ARM with drusen, areas of increased FAF showed normal or near-normal photopic sensitivity, but moderately reduced scotopic sensitivity.

CONCLUSIONS. In retinal areas of increased FAF in patients with ARM, scotopic sensitivity loss considerably exceeded photopic sensitivity loss. This finding is in line with histologic data that have demonstrated a preferential loss of rods in ARM, but does not explain the magnitude of sensitivity loss. The study shows that increased FAF in ARM has a functional correlate.

This article has been cited by other articles:

				M. J. Kanis, R. P. L. Wisse, T. T. J. M. Berendschot, J. van de Kraats, and D. van Norren Foveal Cone-Photoreceptor Integrity in Aging Macula Disorder Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 2077 - 2081. [Abstract] [Full Text] [PDF]

				S. Schmitz-Valckenberg, K. Fan, A. Nugent, G. S. Rubin, T. Peto, A. Tufail, C. Egan, A. C. Bird, and F. W. Fitzke Correlation of Functional Impairment and Morphological Alterations in Patients With Group 2A Idiopathic Juxtafoveal Retinal Telangiectasia Arch Ophthalmol, March 1, 2008; 126(3): 330 - 335. [Abstract] [Full Text] [PDF]

				A G Robson, M Michaelides, V A Luong, G E Holder, A C Bird, A R Webster, A T Moore, and F W Fitzke Functional correlates of fundus autofluorescence abnormalities in patients with RPGR or RIMS1 mutations causing cone or cone rod dystrophy Br. J. Ophthalmol., January 1, 2008; 92(1): 95 - 102. [Abstract] [Full Text] [PDF]

				E. Midena, S. Vujosevic, E. Convento, A. Manfre', F. Cavarzeran, and E. Pilotto Microperimetry and fundus autofluorescence in patients with early age-related macular degeneration Br. J. Ophthalmol., November 1, 2007; 91(11): 1499 - 1503. [Abstract] [Full Text] [PDF]

				P. J. Coffey, C. Gias, C. J. McDermott, P. Lundh, M. C. Pickering, C. Sethi, A. Bird, F. W. Fitzke, A. Maass, L. L. Chen, et al. Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction PNAS, October 16, 2007; 104(42): 16651 - 16656. [Abstract] [Full Text] [PDF]

				C. Abeywickrama, H. Matsuda, S. Jockusch, J. Zhou, Y. P. Jang, B.-X. Chen, Y. Itagaki, B. F. Erlanger, K. Nakanishi, N. J. Turro, et al. Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells PNAS, September 11, 2007; 104(37): 14610 - 14615. [Abstract] [Full Text] [PDF]

				M. Michaelides, S. A. Jenkins, M. A. Brantley Jr, R. M. Andrews, N. Waseem, V. Luong, K. Gregory-Evans, S. S. Bhattacharya, F. W. Fitzke, and A. R. Webster Maculopathy Due to the R345W Substitution in Fibulin-3: Distinct Clinical Features, Disease Variability, and Extent of Retinal Dysfunction. Invest. Ophthalmol. Vis. Sci., July 1, 2006; 47(7): 3085 - 3097. [Abstract] [Full Text] [PDF]

				C. Owsley, G. McGwin, G. R. Jackson, D. C. Heimburger, C. J. Piyathilake, R. Klein, M. F. White, and K. Kallies Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy. Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1310 - 1318. [Abstract] [Full Text] [PDF]

				C. Gerth, P. B. Delahunt, S. Alam, L. S. Morse, and J. S. Werner Cone-Mediated Multifocal Electroretinogram in Age-Related Macular Degeneration: Progression Over a Long-term Follow-up. Arch Ophthalmol, March 1, 2006; 124(3): 345 - 352. [Abstract] [Full Text] [PDF]

				A. Bindewald, A. C. Bird, S. S. Dandekar, J. Dolar-Szczasny, J. Dreyhaupt, F. W. Fitzke, W. Einbock, F. G. Holz, J. J. Jorzik, C. Keilhauer, et al. Classification of Fundus Autofluorescence Patterns in Early Age-Related Macular Disease Invest. Ophthalmol. Vis. Sci., September 1, 2005; 46(9): 3309 - 3314. [Abstract] [Full Text] [PDF]

				A Bindewald, S Schmitz-Valckenberg, J J Jorzik, J Dolar-Szczasny, H Sieber, C Keilhauer, A W A Weinberger, S Dithmar, D Pauleikhoff, U Mansmann, et al. Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration Br. J. Ophthalmol., July 1, 2005; 89(7): 874 - 878. [Abstract] [Full Text] [PDF]

				S. Schmitz-Valckenberg, S. Bultmann, J. Dreyhaupt, A. Bindewald, F. G. Holz, and K. Rohrschneider Fundus Autofluorescence and Fundus Perimetry in the Junctional Zone of Geographic Atrophy in Patients with Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4470 - 4476. [Abstract] [Full Text] [PDF]

				A. G. Robson, C. A. Egan, V. A. Luong, A. C. Bird, G. E. Holder, and F. W. Fitzke Comparison of Fundus Autofluorescence with Photopic and Scotopic Fine-Matrix Mapping in Patients with Retinitis Pigmentosa and Normal Visual Acuity Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 4119 - 4125. [Abstract] [Full Text] [PDF]

				H. P. N. Scholl, N. H. V. Chong, A. G. Robson, G. E. Holder, A. T. Moore, and A. C. Bird Fundus Autofluorescence in Patients with Leber Congenital Amaurosis Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2747 - 2752. [Abstract] [Full Text] [PDF]