IOVS Molecular Human Reproduction
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2004;45:2660-2665.)
© 2004 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.03-1363
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jonas, J. B.
Right arrow Articles by Holbach, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jonas, J. B.
Right arrow Articles by Holbach, L.

Lamina Cribrosa Thickness and Spatial Relationships between Intraocular Space and Cerebrospinal Fluid Space in Highly Myopic Eyes

Jost B. Jonas,1 Eduard Berenshtein,1 and Leonard Holbach2

1From the Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany; and the 2Department of Ophthalmology, University Erlangen-Nürnberg, Erlangen, Germany.

PURPOSE. To evaluate the spatial relationships of the intraocular space, the cerebrospinal fluid space, and the lamina cribrosa in highly myopic eyes.

METHODS. The study included 36 human globes with an axial length of more than 26.5 mm that showed marked glaucomatous optic nerve damage (n = 29; highly myopic glaucomatous group) or in which the optic nerve was affected by neither glaucoma nor any other disease (n = 7; highly myopic normal group). Two non–highly myopic control groups included 53 globes enucleated because of malignant choroidal melanoma (n = 42; non–highly myopic normal group) or because of painful absolute secondary angle-closure glaucoma (n = 11; non–highly myopic glaucomatous group). Anterior–posterior histologic sections through the pupil and the optic disc were morphometrically evaluated.

RESULTS. In both highly myopic groups compared with both non–highly myopic groups and in the highly myopic glaucomatous group compared with the highly myopic normal group, the lamina cribrosa was significantly (P < 0.001) thinner. Correspondingly, the distance between the intraocular space and the cerebrospinal fluid space was significantly (P < 0.05) shorter in the highly myopic normal group than in the non–highly myopic normal group and in the highly myopic glaucomatous group than in the highly myopic normal group.

CONCLUSIONS. In highly myopic eyes, the lamina cribrosa is significantly thinner than in non–highly myopic eyes, which decreases the distance between the intraocular space and the cerebrospinal fluid space and steepens the translaminar pressure gradient at a given intraocular pressure, which may explain the increased susceptibility to glaucoma in highly myopic eyes. As in non–highly myopic eyes, thinning of the lamina cribrosa gets more pronounced in highly myopic eyes if glaucoma is also present.




This article has been cited by other articles:


Home page
 Br. J. Ophthalmol.Home page
K. Y C Lee, F. Rensch, T. Aung, L. S Lim, R. Husain, G. Gazzard, S. K L Seah, and J. B Jonas
Peripapillary atrophy after acute primary angle closure
Br. J. Ophthalmol., August 1, 2007; 91(8): 1059 - 1061.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. E. A. Somner, D. S. Morris, K. M. Scott, I. J. C. MacCormick, P. Aspinall, and B. Dhillon
What Happens to Intraocular Pressure at High Altitude?
Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1622 - 1626.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
C Oliveira, N Harizman, C A Girkin, A Xie, C Tello, J M Liebmann, and R Ritch
Axial length and optic disc size in normal eyes
Br. J. Ophthalmol., January 1, 2007; 91(1): 37 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
M. T. Nicolela, A. S. Soares, M. M. Carrillo, B. C. Chauhan, R. P. LeBlanc, and P. H. Artes
Effect of moderate intraocular pressure changes on topographic measurements with confocal scanning laser tomography in patients with glaucoma.
Arch Ophthalmol, May 1, 2006; 124(5): 633 - 640.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
I. A. Sigal, J. G. Flanagan, and C. R. Ethier
Factors Influencing Optic Nerve Head Biomechanics
Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 4189 - 4199.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
B C Chauhan, D M Hutchison, R P LeBlanc, P H Artes, and M T Nicolela
Central corneal thickness and progression of the visual field and optic disc in glaucoma
Br. J. Ophthalmol., August 1, 2005; 89(8): 1008 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
J B Jonas, T Theelen, and C F M Meulendijks
Tight necktie, intraocular pressure, and intracranial pressure
Br. J. Ophthalmol., June 1, 2005; 89(6): 786 - 787.
[Full Text] [PDF]

Home page
 IOVSHome page
J. B. Jonas and L. Holbach
Central Corneal Thickness and Thickness of the Lamina Cribrosa in Human Eyes
Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1275 - 1279.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Association for Research in Vision and Ophthalmology