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(Investigative Ophthalmology and Visual Science. 2004;45:3203-3206.)
© 2004 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.03-1176
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Characterization of Uveoscleral Outflow in Enucleated Porcine Eyes Perfused under Constant Pressure

Justin A. Wagner,1 Aurélie Edwards,1 and Joel S. Schuman2

1From the Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts; and the 2Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

PURPOSE. A new technique was developed to measure the flow of aqueous humor through the uveoscleral pathway in porcine eyes and to examine whether there is any outflow through the choroid into the vortex veins.

METHODS. Enucleated porcine eyes were perfused in vitro under a constant pressure of 10 mm Hg. After total outflow was measured, the episcleral vessels were blocked with cyanoacrylate to eliminate outflow through the conventional pathway. The vortex veins were then blocked, to assess the amount of choroidal drainage.

RESULTS. The average outflow in control eyes was found to be 2.8 ± 0.9 µL/min. After the exit sites of the conventional pathway were blocked, the average outflow decreased to 1.1 ± 0.5 µL/min. Blocking the vortex veins did not appear to alter uveoscleral outflow further (1.2 ± 0.8 µL/min).

CONCLUSIONS. The results suggest that choroidal drainage into the vortex veins is insignificant in the absence of blood perfusion. No significant washout effects in porcine eyes were observed.






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