IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2005;46:4016-4023.)
© 2005 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.05-0072
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Espallargues, M.
Right arrow Articles by Brazier, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Espallargues, M.
Right arrow Articles by Brazier, J. E.

The Impact of Age-Related Macular Degeneration on Health Status Utility Values

Mireia Espallargues,1,2 Carolyn J. Czoski-Murray,1 Nicholas J. Bansback,1 Jill Carlton,3 Grace M. Lewis,3 Lindsey A. Hughes,3 Christopher S. Brand,4 and John E. Brazier1

1From the Health Economics and Decision Science, University of Sheffield, Sheffield, United Kingdom; the 2Catalan Agency for Health Technology Assessment and Research, Catalan Health Service, Catalan, Spain; and the 3Departments of Orthoptics and 4Ophthalmology, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom.

PURPOSE. To estimate health status utility values in patients with age-related macular degeneration (ARMD) associated with visual impairments, by using preference-based measures of health.

METHOD. This was a cross-sectional study involving patients with unilateral or bilateral ARMD who attended a large teaching hospital. Patients underwent visual tests (near and distant visual acuity [VA] and contrast sensitivity [CS]) and completed health status questionnaires including the Index of Visual Function (VF)-14 and three preference-based measures (the Health Utilities Index Mark III [HUI-3], the EuroQoL Health Questionnaire [EQ-5D], and the Short Form 6D Health Status Questionnaire [SF-6D]) and the time tradeoff (TTO). The mean health status is presented for five groups, defined according to the VA in the better-seeing eye and for four CS groups.

RESULTS. Two hundred nine patients were recruited with substantial loss of visual function as obtained by visual tests (mean decimal VA in the better-seeing eye: 0.2) and self-report (mean VF-14 score: 41.5). The mean (±SD) utilities were 0.34 ± 0.28 for HUI-3, 0.66 ± 0.14 for SF-6D, 0.72 ± 0.22 for EQ-5D, and 0.64 ± 0.31 for TTO. The HUI-3 had the highest correlation with VA and CS (0.40 and –0.34), followed by TTO (0.25 and –0.21). Across the VA and CS groups, only HUI3 and TTO had a significant linear trend (P < 0.05). In a regression model with CS and VA as explanatory variables, only the coefficient on CS was statistically significant.

CONCLUSIONS. ARMD is associated with a substantial impact on patients’ health status, but this was not reflected in two of the generic preference-based measures used. The HUI-3 seems to be the instrument of choice for use in economic evaluations in which community data are needed. It may be more appropriate to base economic models on CS or some combination of CS and VA rather than on VA alone.




This article has been cited by other articles:


Home page
 Obstet GynecolHome page
K. Dickersin, M. G. Munro, M. Clark, P. Langenberg, R. Scherer, K. Frick, Q. Zhu, L. Hallock, J. Nichols, T. M. Yalcinkaya, et al.
Hysterectomy Compared With Endometrial Ablation for Dysfunctional Uterine Bleeding: A Randomized Controlled Trial
Obstet. Gynecol., December 1, 2007; 110(6): 1279 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
A. Lotery, X. Xu, G. Zlatava, and J. Loftus
Burden of illness, visual impairment and health resource utilisation of patients with neovascular age-related macular degeneration: results from the UK cohort of a five-country cross-sectional study
Br. J. Ophthalmol., October 1, 2007; 91(10): 1303 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
G. Soubrane, A. Cruess, A. Lotery, D. Pauleikhoff, J. Mones, X. Xu, G. Zlateva, R. Buggage, J. Conlon, and T. F. Goss
Burden and Health Care Resource Utilization in Neovascular Age-Related Macular Degeneration: Findings of a Multicountry Study
Arch Ophthalmol, September 1, 2007; 125(9): 1249 - 1254.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
J. Mitchell
Investigating the Burden of Wet Macular Degeneration
Arch Ophthalmol, September 1, 2007; 125(9): 1266 - 1268.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the Association for Research in Vision and Ophthalmology