IOVS Journal of Clinical Investigation
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2005;46:442-446.)
© 2005 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.04-0794
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Klein, A. P.
Right arrow Articles by Klein, B. E. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klein, A. P.
Right arrow Articles by Klein, B. E. K.

Support for Polygenic Influences on Ocular Refractive Error

Alison P. Klein,1 Priya Duggal,1 Kristine E. Lee,2 Ronald Klein,2 Joan E. Bailey-Wilson,1 and Barbara E. K. Klein2

1From the Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, Baltimore, Maryland; and the 2Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin.

PURPOSE. Refractive errors, myopia, and hyperopia are common conditions requiring corrective lenses. The familial clustering of myopia has been well established. Several chromosomal regions have been linked to high myopia (12q, 17q, and 18q), to quantitative refraction among twins (3q, 4q, 8p, and 11p), and to families with moderate myopia (22q). This study examined the familial aggregation and pattern of inheritance of ocular refraction in an adult population, by using data from the Beaver Dam Eye Study.

METHODS. Familial correlations were examined and segregation analysis was performed on the average refractive error measurements in the right and left eyes after adjustment for age, sex, and education. Analyses were based on 2138 individuals in 620 extended pedigrees with complete data on age, sex, education, and spherical equivalent.

RESULTS. Substantial positive correlation was found between siblings (0.33), parents and offspring (0.17), and cousins (0.10) and lower correlation among avuncular pairs (0.08) after adjustment for age, sex, and years of education. The results of this segregation analysis do not support the involvement of a single major locus throughout the entire range of refractive error. However, models allowing for familial correlation, attributable in part to polygenic effects, provided a better fit to the observed data than models without a polygenic component, suggesting that several genes of modest effect may influence refractive error, possibly in conjunction with environmental factors.

CONCLUSIONS. These results support the involvement of genetic factors in the etiology of refractive error and are consistent with reports of linkage to multiple regions of the genome.




This article has been cited by other articles:


Home page
 IOVSHome page
C. Y. Lam, P. O. S. Tam, D. S. P. Fan, B. J. Fan, D. Y. Wang, C. W. S. Lee, C. P. Pang, and D. S. C. Lam
A Genome-wide Scan Maps a Novel High Myopia Locus to 5p15
Invest. Ophthalmol. Vis. Sci., September 1, 2008; 49(9): 3768 - 3778.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
A. Fotouhi, A. Etemadi, H. Hashemi, H. Zeraati, J. E Bailey-Wilson, and K. Mohammad
Familial aggregation of myopia in the Tehran eye study: estimation of the sibling and parent offspring recurrence risk ratios
Br. J. Ophthalmol., November 1, 2007; 91(11): 1440 - 1444.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. M. Ip, S. C. Huynh, D. Robaei, K. A. Rose, I. G. Morgan, W. Smith, A. Kifley, and P. Mitchell
Ethnic Differences in the Impact of Parental Myopia: Findings from a Population-Based Study of 12-Year-Old Australian Children
Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2520 - 2528.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. K. Gupta, G. V. S. Murthy, N. Morrison, G. M. Price, M. Dherani, N. John, A. E. Fletcher, and U. Chakravarthy
Prevalence of Early and Late Age-Related Macular Degeneration in a Rural Population in Northern India: The INDEYE Feasibility Study
Invest. Ophthalmol. Vis. Sci., March 1, 2007; 48(3): 1007 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
T. L. Young, R. Metlapally, and A. E. Shay
Complex Trait Genetics of Refractive Error
Arch Ophthalmol, January 1, 2007; 125(1): 38 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
A. P. Klein, P. Duggal, K. E. Lee, R. Klein, J. E. Bailey-Wilson, and B. E. K. Klein
Confirmation of Linkage to Ocular Refraction on Chromosome 22q and Identification of a Novel Linkage Region on 1q
Arch Ophthalmol, January 1, 2007; 125(1): 80 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
S-M Saw, P-P Goh, A Cheng, A Shankar, D T H Tan, and L B Ellwein
Ethnicity-specific prevalences of refractive errors vary in Asian children in neighbouring Malaysia and Singapore
Br. J. Ophthalmol., October 1, 2006; 90(10): 1230 - 1235.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. Klein and B. E. K. Klein
The Epidemiology of Eye Disease: From Glycemia to Genetics The Friedenwald Lecture
Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1747 - 1753.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the Association for Research in Vision and Ophthalmology