| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1From the Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida; and the 2Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
PURPOSE. To determine the reproducibility of Stratus Optical Coherence Tomography (OCT) retinal nerve fiber layer (RNFL) measurements around the optic nerve in normal and glaucomatous eyes.
METHODS. One eye was chosen at random from 88 normal subjects and 59 glaucomatous subjects distributed among mild, moderate, and severe glaucoma, determined by visual field testing. Subjects underwent six RNFL thickness measurements performed by a single operator over a 30-minute period with a brief rest between sessions. Three scans were taken with the high-density Standard RNFL protocol, and three were taken with the Fast RNFL protocol, alternating between scan protocols.
RESULTS. Reliability, as measured by intraclass correlation coefficient (ICC), was calculated for the overall mean RNFL thickness and for each quadrant. The ICC for the mean Standard RNFL thickness (and lower 95% confidence interval [CI]) in normal and glaucomatous eyes was 0.97 (0.96 CI) and 0.98 (0.97 CI), respectively. The ICC for the mean Fast RNFL thickness in normal and glaucomatous eyes was 0.95 (0.93 CI) and 0.97 (0.95 CI), respectively. Quadrant ICCs ranged between 0.79 and 0.97, with the nasal quadrant being the least reproducible of all four quadrants, using either the Standard or Fast RNFL program. The test–retest variability ranged from 3.5 µm for the average RNFL thickness measurements in normal eyes to 13.8 µm for the nasal quadrant measurements in glaucomatous eyes, which appeared to be the most variable.
CONCLUSIONS. Reproducibility of RNFL measurements using the Stratus OCT is excellent in normal and glaucomatous eyes. The nasal quadrant appears to be the most variable measurement. Standard RNFL and Fast RNFL scans are equally reproducible and yield comparable measurements. These findings have implications for the diagnosis of glaucoma and glaucomatous progression.
This article has been cited by other articles:
|
|
 |
|
  G Vizzeri, R N Weinreb, A O Gonzalez-Garcia, C Bowd, F A Medeiros, P A Sample, and L M Zangwill Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness Br. J. Ophthalmol., June 1, 2009; 93(6): 775 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Archibald, M. P. Clarke, U. P. Mosimann, and D. J. Burn The retina in Parkinson's disease Brain, May 1, 2009; 132(5): 1128 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Menke, P. Knecht, V. Sturm, S. Dabov, and J. Funk Reproducibility of Nerve Fiber Layer Thickness Measurements Using 3D Fourier-Domain OCT Invest. Ophthalmol. Vis. Sci., December 1, 2008; 49(12): 5386 - 5391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K.-s. Leung, C. Y.-l. Cheung, D. Lin, C. P. Pang, D. S. C. Lam, and R. N. Weinreb Longitudinal Variability of Optic Disc and Retinal Nerve Fiber Layer Measurements Invest. Ophthalmol. Vis. Sci., November 1, 2008; 49(11): 4886 - 4892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kanamori, M. Naka, A. Nagai-Kusuhara, Y. Yamada, M. Nakamura, and A. Negi Regional Relationship Between Retinal Nerve Fiber Layer Thickness and Corresponding Visual Field Sensitivity in Glaucomatous Eyes Arch Ophthalmol, November 1, 2008; 126(11): 1500 - 1506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Cettomai, M. Pulicken, E. Gordon-Lipkin, A. Salter, T. C. Frohman, A. Conger, X. Zhang, G. Cutter, L. J. Balcer, E. M. Frohman, et al. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis Arch Neurol, September 1, 2008; 65(9): 1218 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S A Vernon, A P Rotchford, A Negi, S Ryatt, and C Tattersal Peripapillary retinal nerve fibre layer thickness in highly myopic Caucasians as measured by Stratus optical coherence tomography Br. J. Ophthalmol., August 1, 2008; 92(8): 1076 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Martinez, N Proupim, and M Sanchez Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients Br. J. Ophthalmol., August 1, 2008; 92(8): 1069 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ferreras, L. E. Pablo, D. F. Garway-Heath, P. Fogagnolo, and J. Garcia-Feijoo Mapping Standard Automated Perimetry to the Peripapillary Retinal Nerve Fiber Layer in Glaucoma Invest. Ophthalmol. Vis. Sci., July 1, 2008; 49(7): 3018 - 3025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, et al. Optical Coherence Tomography Scan Circle Location and Mean Retinal Nerve Fiber Layer Measurement Variability Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2315 - 2321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Kagemann, T Mumcuoglu, G Wollstein, R Bilonick, H Ishikawa, K A Townsend, M Gabriele, J G Fujimoto, and J S Schuman Sources of longitudinal variability in optical coherence tomography nerve-fibre layer measurements Br. J. Ophthalmol., June 1, 2008; 92(6): 806 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Cheng, M. Laron, J. S. Schiffman, R. A. Tang, and L. J. Frishman The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5798 - 5805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman Peripapillary Nerve Fiber Layer Thickness Profile Determined with High Speed, Ultrahigh Resolution Optical Coherence Tomography High-Density Scanning Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3154 - 3160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K.-s. Leung, F. A. Medeiros, L. M. Zangwill, P. A. Sample, C. Bowd, D. Ng, C. Y. L. Cheung, D. S. C. Lam, and R. N. Weinreb American Chinese Glaucoma Imaging Study: A Comparison of the Optic Disc and Retinal Nerve Fiber Layer in Detecting Glaucomatous Damage Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2644 - 2652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Harwerth, A. S. Vilupuru, N. V. Rangaswamy, and E. L. Smith III The Relationship between Nerve Fiber Layer and Perimetry Measurements Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 763 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K.-S. Leung, S. Mohamed, K. S. Leung, C. Y.-L. Cheung, S. L.-w. Chan, D. K.-y. Cheng, A. K.-c. Lee, G. Y.-o. Leung, S. K. Rao, and D. S. C. Lam Retinal Nerve Fiber Layer Measurements in Myopia: An Optical Coherence Tomography Study Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5171 - 5176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sihota, P. Sony, V. Gupta, T. Dada, and R. Singh Diagnostic Capability of Optical Coherence Tomography in Evaluating the Degree of Glaucomatous Retinal Nerve Fiber Damage Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 2006 - 2010. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
