IOVS Journal of Bacteriology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2005;46:3046-3051.)
© 2005 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.04-1277
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sivaprasad, S.
Right arrow Articles by Bailey, T. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sivaprasad, S.
Right arrow Articles by Bailey, T. A.

Serum Elastin-Derived Peptides in Age-Related Macular Degeneration

Sobha Sivaprasad,1,2 Ngaihang Victor Chong,1 and Tracey A. Bailey2

1From the Laser and Retinal Research Unit, King’s College Hospital, University of London, London, United Kingdom; and the 2Cranfield BioMedical Centre, Cranfield University at Silsoe, Bedfordshire, United Kingdom.

PURPOSE. Dysregulation of the extracellular matrix (ECM) plays an important role in the pathogenesis of age-related macular degeneration (AMD). Elastin is a fibrous protein constituent of the ECM, degradation of which may be detected by the presence of serum elastin-derived peptides (S-EDPs) in circulation. This study was undertaken to estimate levels of S-EDPs in patients with AMD compared with age-matched control subjects.

METHODS. Fifty-six patients with AMD were classified into two groups: early age-related maculopathy (ARM) and neovascular AMD. The control group consisted of 15 age-matched subjects with no AMD. S-EDP levels in the serum of these subjects was estimated by competitive ELISA, using solubilized {alpha}-elastin from human aorta and polyclonal antibodies to this antigen.

RESULTS. S-EDPs were significantly higher in patients with AMD than in control subjects. In addition, subjects with neovascular AMD had higher levels of S-EDPs than did those with early disease.

CONCLUSIONS. The cause of this association between S-EDPs and AMD is unknown, but it suggests that systemic elastin degradation may increase the risk of conversion from early ARM to neovascular AMD. Further studies are needed to confirm whether the serum level of S-EDPs is a useful predictor of conversion from early ARM to neovascular AMD.




This article has been cited by other articles:


Home page
 IOVSHome page
H. G. Yu, X. Liu, S. Kiss, E. Connolly, E. S. Gragoudas, N. A. Michaud, O. V. Bulgakov, M. Adamian, M. M. DeAngelis, J. W. Miller, et al.
Increased Choroidal Neovascularization following Laser Induction in Mice Lacking Lysyl Oxidase-like 1
Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2599 - 2605.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the Association for Research in Vision and Ophthalmology