| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ay,21From the Department of Ophthalmology, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria; the 2Center for Biomedical Engineering and Physics, Christian Doppler Laboratory, Medical University of Vienna, Vienna, Austria.
PURPOSE. To demonstrate a new generation of three-dimensional (3-D) ultrahigh-resolution optical coherence tomography (UHR OCT) technology for visualization of macular diseases.
METHODS. One hundred forty eyes with a distinct disease in each of the posterior pole compartments were examined with 3-D UHR OCT. 3-D imaging was performed with a high axial resolution of 3 µm with a compact, commercially available, ultra–broad-bandwidth (160 nm) titanium:sapphire laser at a video rate of up to 25 B-scans/s. Each tomogram consisted of 1024 x 1024 pixels, resulting in 25 megavoxels/s.
RESULTS. 3-D UHR OCT offers high-precision 3-D visualization of macular diseases at all structural levels. The UHR modality allows identification of the contour of the hyaloid membrane, tractive forces of epiretinal membranes, and changes within the inner limiting membrane. The system provides quality 3-D images of the topographic dynamics of traction lines from the retinal surface down to the level of the photoreceptor segments. Intraretinal diseases are identified by their specific location in different layers of the neurosensory ultrastructure. Photoreceptor inner and outer segments are clearly delineated in configuration and size, with a characteristic peak in the subfoveal area. The microarchitecture of choroidal neovascularization is distinctly imaged, related leakage can be identified, and the volume can be quantified.
CONCLUSIONS. High-speed UHR OCT offers unprecedented, realistic, 3-D imaging of ocular diseases at all epi-, intra- and subretinal levels. A complete 3-D data set of the macular layers allows a comprehensive analysis of focal and diffuse diseases, as well as identification of dynamic pathomechanisms.
This article has been cited by other articles:
|
|
 |
|
  M. Fleckenstein, P. C. Issa, H.-M. Helb, S. Schmitz-Valckenberg, R. P. Finger, H. P. N. Scholl, K. U. Loeffler, and F. G. Holz High-Resolution Spectral Domain-OCT Imaging in Geographic Atrophy Associated with Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., September 1, 2008; 49(9): 4137 - 4144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Daniele, B. Sauer, S. M. Gallagher, E. N. Pugh Jr, and N. J. Philp Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice Am J Physiol Cell Physiol, August 1, 2008; 295(2): C451 - C457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto Characterization of Outer Retinal Morphology with High-Speed, Ultrahigh-Resolution Optical Coherence Tomography Invest. Ophthalmol. Vis. Sci., April 1, 2008; 49(4): 1571 - 1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Michels, M Pircher, W Geitzenauer, C Simader, E Gotzinger, O Findl, U Schmidt-Erfurth, and C K Hitzenberger Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium Br. J. Ophthalmol., February 1, 2008; 92(2): 204 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Ahlers, C Simader, W Geitzenauer, G Stock, P Stetson, S Dastmalchi, and U Schmidt-Erfurth Automatic segmentation in three-dimensional analysis of fibrovascular pigmentepithelial detachment using high-definition optical coherence tomography Br. J. Ophthalmol., February 1, 2008; 92(2): 197 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Drexler Cellular and Functional Optical Coherence Tomography of the Human Retina The Cogan Lecture Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5340 - 5351. [Full Text] [PDF]
|
|
|
|
|
|
E. Gotzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger Imaging of Birefringent Properties of Keratoconus Corneas by Polarization-Sensitive Optical Coherence Tomography Invest. Ophthalmol. Vis. Sci., August 1, 2007; 48(8): 3551 - 3558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Rodriguez-Padilla, T. R. Hedges III, B. Monson, V. Srinivasan, M. Wojtkowski, E. Reichel, J. S. Duker, J. S. Schuman, and J. G. Fujimoto High-Speed Ultra-High-Resolution Optical Coherence Tomography Findings in Hydroxychloroquine Retinopathy Arch Ophthalmol, June 1, 2007; 125(6): 775 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Schmidt-Erfurth, K. Kriechbaum, and A. Oldag Three-Dimensional Angiography of Classic and Occult Lesion Types in Choroidal Neovascularization Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1751 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pircher, E. Gotzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger Human Macula Investigated In Vivo with Polarization-Sensitive Optical Coherence Tomography Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5487 - 5494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S.-E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, et al. Noninvasive Volumetric Imaging and Morphometry of the Rodent Retina with High-Speed, Ultrahigh-Resolution Optical Coherence Tomography Invest. Ophthalmol. Vis. Sci., December 1, 2006; 47(12): 5522 - 5528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K A Goatman A reference standard for the measurement of macular oedema. Br. J. Ophthalmol., September 1, 2006; 90(9): 1197 - 1202. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
