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(Investigative Ophthalmology and Visual Science. 2006;47:4288-4294.)
© 2006 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.05-1469
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Identical Excimer Laser PTK Treatments in Rabbits Result in Two Distinct Haze Responses

Russell L. McCally,1,2 Patrick J. Connolly,2,3 Walter J. Stark,2 Sandeep Jain,2,4 and Dimitri T. Azar2,4

1From the The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland; and 2The Wilmer Eye Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland. 3Present affiliation: Indianapolis Neurosurgical Group, Indianapolis, Indiana; and the 4Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois.

PURPOSE. To obtain objective light-scattering measurements to test a hypothesis that identical PTK treatments cause distinct low- and high-level light-scattering responses in rabbit corneas.

METHODS. An excimer laser was used to produce identical 6-mm diameter phototherapeutic keratectomy treatments (PTK) in 32 pigmented rabbits. Eyes were treated by performing a 40-µm epithelial ablation, followed by a 100-µm stromal PTK. Objective scattering measurements were made before treatment, weekly up to 5 weeks, and then biweekly to 9 weeks. Confocal microscopy was performed on several corneas at 4 and 7 weeks.

RESULTS. Mean scattering levels split into distinct low- and high-scattering groups 2 weeks after treatment and remained distinct until week 7 (P < 0.003). Scattering in the low group reached a broad peak that lasted from weeks 2 to 4 at approximately 3 times the pretreatment level. Scattering in the high group peaked at 3 weeks at approximately 12 times the pretreatment level. Scattering levels diminished after reaching their peaks. Confocal images showed a band of highly reflective material in the anterior stroma that extended much deeper in corneas from the high group. The reflective band in the highly scattering corneas obscured the posterior stroma from view for up to 5 weeks.

CONCLUSIONS. Quantitative scattering data obtained with the scatterometer suggest that identical PTK treatments indeed result in distinct low- and high-level light-scattering responses in rabbits.






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Copyright © 2006 by the Association for Research in Vision and Ophthalmology