HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Davis, A. R. Articles by Holder, G. E. Search for Related Content PubMed PubMed Citation Articles by Davis, A. R. Articles by Holder, G. E.

Differential Changes of Magnocellular and Parvocellular Visual Function in Early- and Late-Onset Strabismic Amblyopia

¹From the Moorfields Eye Hospital, London, United Kingdom; and ²City University, London, United Kingdom.

PURPOSE. Studies in nonhuman primates show that monocular visual deprivation starting at different ages has different effects on cells in the parvocellular and magnocellular laminae of the lateral geniculate nucleus. The present study used color and luminance contrast sensitivity (CS) measurements to look for differences in parvocellular- and magnocellular-related visual function in human subjects with strabismic amblyopia.

METHODS. Fifteen subjects with early- and 14 with late-onset strabismic amblyopia and similar ranges of visual acuity were studied, together with 15 subjects with normal vision. Contrast sensitivities were measured to an equiluminant (L-M cone-modulated) grating with slow onset and an achromatic (L+M cone-modulated) 0.8-cpd grating with rapid onset using an adaptive method.

RESULTS. Luminance and color CS were lower in the amblyopic eyes than in the fellow eyes of all amblyopes. For luminance CS, this was due both to an increase in sensitivity of the fellow eye and to a reduction in sensitivity in the amblyopic eye. Color CS was greatly reduced in the amblyopic and fellow eyes of subjects with strabismic amblyopia of early- and late onset compared with subjects with normal vision. The reduction in color CS compared with luminance CS was significantly greater in eyes with late- rather than early-onset amblyopia.

CONCLUSIONS. Parvocellular and magnocellular function are differentially affected in the amblyopic and fellow eyes of subjects with strabismic amblyopia. The difference is more marked in late-onset amblyopia than in early-onset amblyopia.

This article has been cited by other articles:

				A. R. Davis, J. J. Sloper, M. M. Neveu, C. R. Hogg, M. J. Morgan, and G. E. Holder Differential Changes in Color and Motion-Onset Visual Evoked Potentials from Both Eyes in Early- and Late-Onset Strabismic Amblyopia Invest. Ophthalmol. Vis. Sci., October 1, 2008; 49(10): 4418 - 4426. [Abstract] [Full Text] [PDF]

				A. J. Zele, J. Pokorny, D. Y. Lee, and D. Ireland Anisometropic Amblyopia: Spatial Contrast Sensitivity Deficits in Inferred Magnocellular and Parvocellular Vision Invest. Ophthalmol. Vis. Sci., August 1, 2007; 48(8): 3622 - 3631. [Abstract] [Full Text] [PDF]