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(Investigative Ophthalmology and Visual Science. 2006;47:501-508.)
© 2006 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.05-0323
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Prevalence and Treatment of Helicobacter pylori in Patients with Blepharitis

Sergio Claudio Saccà,1 Antonio Pascotto,1 Gian Maria Venturino,1 Guido Prigione,1 Antonio Mastromarino,1 Franco Baldi,1 Claudio Bilardi,2 Vincenzo Savarino,2 Carlo Brusati,3 and Alfredo Rebora3

1From the Department of Neurosciences, Ophthalmology and Genetics, Clinica Oculistica, the 2Department of Internal Medicine, Operative Unit of Gastroenterology, and the 3Department of Endocrinology and Metabolic Diseases, Section of Dermatology, University of Genoa, Genoa, Italy.

PURPOSE. Helicobacter pylori is a major pathogen etiologically associated with gastritis, peptic ulcer disease, gastric cancer, and primary gastric lymphoma. This study was conducted to investigate a possible association between Helicobacter pylori infection and blepharitis. Two hundred fifty consecutive patients with symptomatic blepharitis and 250 control subjects without blepharitis symptoms were evaluated. After exclusions, the blepharitis group consisted of 186 patients with blepharitis and a control group of 215 patients.

METHODS. Blepharitis was diagnosed on the basis of findings in ophthalmic and dermatologic examinations. All patients underwent a 13C-urea breath test (UBT) to detect H. pylori infection, and impression cytology was performed before and after eradication therapy. The follow-up period was 4 months ± 28 days.

RESULTS. The blepharitis group showed an H. pylori infection prevalence of approximately 76.3% (UBT-positive group with blepharitis: n = 142 patients), compared with 42.3% of the control group (UBT-positive group with blepharitis [although asymptomatic]: n = 66 patients; UBT-positive group without blepharitis: n = 25 patients). Furthermore, we observed blepharitis in 30.6% (n = 66 patients) of UBT-positive control subjects and 13.4% (n = 29 patients) of UBT-negative control subjects. Impression cytology revealed that blepharitis was more severe in UBT-positive patients than in negative ones, and a clinical improvement in blepharitis was noted in approximately 50% of patients after H. pylori eradication.

CONCLUSIONS. Even though possible sources of error in defining the association of two highly prevalent conditions must be considered, the data seem to validate an association between H. pylori infection and blepharitis, but may not be indicative of a causal association. Eradication of H. pylori improved ocular cytology results. It is possible that chronic blepharitis is an extradigestive manifestation of H. pylori infection.






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