HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplementary Material Submit a response View responses Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Croft, M. A. Articles by Kaufman, P. L. Search for Related Content PubMed PubMed Citation Articles by Croft, M. A. Articles by Kaufman, P. L.

The Zonula, Lens, and Circumlental Space in the Normal Iridectomized Rhesus Monkey Eye

¹From the Department of Ophthalmology and Visual Sciences, Wisconsin Regional Primate Research Center, and ³Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin; and the ²College of Optometry, University of Houston, Houston, Texas.

PURPOSE. To document zonular orientation and suspension of the lens during accommodation, and age-related changes of the circumlental space (CLS) at rest and during accommodation, in living iridectomized rhesus monkey eyes.

METHODS. The CLS was measured in 34 iridectomized eyes of 24 living rhesus monkeys, age 5.7 to 26 years, in the resting and accommodated state, and the orientation of the zonula and suspension of the lens during accommodation was assessed qualitatively.

RESULTS. The nonaccommodated CLS decreased significantly with age in both the nasal and temporal quadrants and tended to do so at a slightly faster rate in the temporal quadrant. The CLS correlated significantly with the accommodative amplitude: the greater the CLS the greater the accommodative amplitude. Multiple regression analysis indicated that age and CLS together are better predictors of accommodative amplitude than is age alone. The zonula appeared taut in the nonaccommodated eye throughout the age range despite the age-related decline in CLS.

CONCLUSIONS. Characterization of age-related changes in the accommodative apparatus may help to model the system for hypothesis testing. The CLS may be an indicator of presbyopia-related processes in surrounding tissues. However, these results do not prove that the width of the CLS, in and of itself, has a causal relationship with accommodative amplitude, or that changes in the CLS play a pathophysiological role in presbyopia.

This article has been cited by other articles:

				F. Manns, J.-M. Parel, D. Denham, C. Billotte, N. Ziebarth, D. Borja, V. Fernandez, M. Aly, E. Arrieta, A. Ho, et al. Optomechanical Response of Human and Monkey Lenses in a Lens Stretcher Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3260 - 3268. [Abstract] [Full Text] [PDF]

				L. A. Ostrin and A. Glasser Effects of Pharmacologically Manipulated Amplitude and Starting Point on Edinger-Westphal-Stimulated Accommodative Dynamics in Rhesus Monkeys Invest. Ophthalmol. Vis. Sci., January 1, 2007; 48(1): 313 - 320. [Abstract] [Full Text] [PDF]

				M. A. Croft, A. Glasser, G. Heatley, J. McDonald, T. Ebbert, D. B. Dahl, N. V. Nadkarni, and P. L. Kaufman Accommodative ciliary body and lens function in rhesus monkeys, I: normal lens, zonule and ciliary process configuration in the iridectomized eye. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 1076 - 1086. [Abstract] [Full Text] [PDF]

eLetters: