HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Barthelmes, D. Articles by Fleischhauer, J. C. Search for Related Content PubMed PubMed Citation Articles by Barthelmes, D. Articles by Fleischhauer, J. C.

Quantitative Analysis of OCT Characteristics in Patients with Achromatopsia and Blue-Cone Monochromatism

From the Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.

PURPOSE. To quantify optical coherence tomography (OCT) images of the central retina in patients with blue-cone monochromatism (BCM) and achromatopsia (ACH) compared with healthy control individuals.

METHODS. The study included 15 patients with ACH, 6 with BCM, and 20 control subjects. Diagnosis of BCM and ACH was established by visual acuity testing, morphologic examination, color vision testing, and Ganzfeld ERG recording. OCT images were acquired with the Stratus OCT 3 (Carl Zeiss Meditec AG, Oberkochen, Germany). Foveal OCT images were analyzed by calculating longitudinal reflectivity profiles (LRPs) from scan lines. Profiles were analyzed quantitatively to determine foveal thickness and distances between reflectivity layers.

RESULTS. Patients with ACH and BCM had a mean visual acuity of 20/200 and 20/60, respectively. Color vision testing results were characteristic of the diseases. The LRPs of control subjects yielded four peaks (P1–P4), presumably representing the RPE (P1), the ovoid region of the photoreceptors (P2), the external limiting membrane (ELM) (P3), and the internal limiting membrane (P4). In patients with ACH, P2 was absent, but foveal thickness (P1–P4) did not differ significantly from that in the control subjects (187 ± 20 vs. 192 ± 14 µm, respectively). The distance from P1 to P3 did not differ significantly (78 ± 10 vs. 82 ± 5 µm) between ACH and controls subjects. In patients with BCM, P3 was lacking, and P2 advanced toward P1 compared with the control subjects (32 ± 6 vs. 48 ± 4 µm). Foveal thickness (153 ± 16 µm) was significantly reduced compared with that in control subjects and patients with ACH.

CONCLUSIONS. Quantitative OCT image analysis reveals distinct patterns for controls subjects and patients with ACH and BCM, respectively. Quantitative analysis of OCT imaging can be useful in differentiating retinal diseases affecting photoreceptors. Foveal thickness is similar in both normal subjects and patients with ACH but is decreased in patients with BCM.

This article has been cited by other articles:

				D. Barthelmes, M. C. Gillies, and F. K. P. Sutter Quantitative OCT Analysis of Idiopathic Perifoveal Telangiectasia Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 2156 - 2162. [Abstract] [Full Text] [PDF]

				C. Tappeiner, D. Barthelmes, M. H. Abegg, S. Wolf, and J. C. Fleischhauer Impact of Optic Media Opacities and Image Compression on Quantitative Analysis of Optical Coherence Tomography Invest. Ophthalmol. Vis. Sci., April 1, 2008; 49(4): 1609 - 1614. [Abstract] [Full Text] [PDF]

				A. Mataftsi, D. F. Schorderet, L. Chachoua, M. Boussalah, M. T. Nouri, D. Barthelmes, F.-X. Borruat, and F. L. Munier Novel TULP1 Mutation Causing Leber Congenital Amaurosis or Early Onset Retinal Degeneration Invest. Ophthalmol. Vis. Sci., November 1, 2007; 48(11): 5160 - 5167. [Abstract] [Full Text] [PDF]

				B. Varsanyi, G. M. Somfai, B. Lesch, R. Vamos, and A. Farkas Optical Coherence Tomography of the Macula in Congenital Achromatopsia Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2249 - 2253. [Abstract] [Full Text] [PDF]