IOVS Biophysical Journal
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2006;47:2061-2064.)
© 2006 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.05-1042
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oishi, N.
Right arrow Articles by Akagi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oishi, N.
Right arrow Articles by Akagi, Y.

Correlation between Adult Diabetic Cataracts and Red Blood Cell Aldose Reductase Levels

Namiki Oishi,1 Soichi Morikubo,1 Yoshihiro Takamura,1 Eri Kubo,1 Shosai Tsuzuki,1 Tsuyoshi Tanimoto,2 and Yoshio Akagi1

1From the Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; and the 2Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Kyoto, Japan.

PURPOSE. To investigate the correlation between adult diabetic cataracts and levels of aldose reductase (AR) in red blood cells (RBCs).

METHODS. The study involved 337 eyes of 337 patients with diabetes. The extent and severity of lens opacity was assessed according to the Lens Opacities Classification System III (LOCS III). The AR levels within RBCs were determined with an ELISA. The relationship between the AR level in RBCs and the prevalence of nuclear cataract, cortical cataract, and posterior subcapsular cataract in patients with diabetes was examined.

RESULTS. There were no significant alterations in AR level in RBCs in patients with a diabetes duration of ≤10 years and patients <60 years of age. In each subgroup, a higher amount of AR levels in RBCs significantly correlated with the prevalence of posterior subcapsular cataracts. A significant association between cortical cataract and AR level in RBCs was also seen in a subgroup of patients younger than 60 years.

CONCLUSIONS. AR emerges as an important factor affecting the onset of posterior subcapsular cataracts at the early stages of diabetes mellitus. This raises the possibility that AR inhibitors could play a useful role in treatment of adult diabetic cataract through its inhibition of AR activities.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Association for Research in Vision and Ophthalmology