HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (18) Citing Articles via Google Scholar Google Scholar Articles by Bowd, C. Articles by Weinreb, R. N. Search for Related Content PubMed PubMed Citation Articles by Bowd, C. Articles by Weinreb, R. N.

Structure–Function Relationships Using Confocal Scanning Laser Ophthalmoscopy, Optical Coherence Tomography, and Scanning Laser Polarimetry

From the Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, California.

PURPOSE. To assess the strength of the association between retinal nerve fiber layer (RNFL) thickness and optic disc topography measured with confocal retinal tomography (HRT II; Heidelberg Engineering, Dossenheim, Germany), optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA), and scanning laser polarimetry (GDx with variable corneal compensator, VCC; Carl Zeiss Meditec, Inc.), and visual field (VF) sensitivity and to determine whether this association is better expressed as a linear or nonlinear function.

METHODS. One hundred twenty-seven patients with glaucoma or suspected glaucoma and 127 healthy eyes from enrollees in the Diagnostic Innovations in Glaucoma Study (DIGS) were tested on HRT II, StratusOCT, GDx VCC, and standard automated perimetry (SAP, with the Swedish Interactive Thresholding Algorithm [SITA]) within 3 months of each other. Linear and logarithmic associations between RNFL thickness (HRT II, StratusOCT, and GDx VCC) and neuroretinal rim area (HRT II) and SAP sensitivity expressed in decibels were determined globally and for six RNFL/optic disc regions (inferonasal, inferotemporal, temporal, superotemporal, superonasal, and nasal) and six corresponding VF regions (superior, superonasal, nasal, inferonasal, inferior, and temporal).

RESULTS. The associations (R²) between global and regional RNFL/optic disc measurements and VF sensitivity ranged from <0.01 (temporal RNFL, nasal VF, and nasal RNFL, temporal VF; linear and logarithmic associations) to 0.26 (inferotemporal RNFL, superonasal VF; logarithmic association) for HRT II; from 0.02 (temporal RNFL, nasal VF; linear association) to 0.38 (inferotemporal RNFL, superonasal VF; logarithmic association) for OCT; and from 0.03 (temporal RNFL, nasal VF; linear association) to 0.21 (inferotemporal RNFL, superonasal VF; logarithmic association) for GDx. Structure–function relationships generally were strongest between the inferotemporal RNFL–optic disc sector and the superonasal visual field and were significantly stronger for StratusOCT RNFL thickness than for other instruments in this region. Global associations (linear and logarithmic) were significantly stronger using OCT compared with HRT. In most cases, logarithmic fits were not significantly better than linear fits when visual sensitivity was expressed in log units (i.e., decibels).

CONCLUSIONS. These results suggest that structure–function associations are strongest with StratusOCT measurements and are similar between HRT II and GDx VCC and these associations are generally no better expressed logarithmically than linearly when healthy, suspect, and glaucomatous eyes are considered.

This article has been cited by other articles:

				S. Machida, Y. Gotoh, Y. Toba, A. Ohtaki, M. Kaneko, and D. Kurosaka Correlation between Photopic Negative Response and Retinal Nerve Fiber Layer Thickness and Optic Disc Topography in Glaucomatous Eyes Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 2201 - 2207. [Abstract] [Full Text] [PDF]

				H. Cheng, M. Laron, J. S. Schiffman, R. A. Tang, and L. J. Frishman The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5798 - 5805. [Abstract] [Full Text] [PDF]

				D. C. Hood, S. C. Anderson, M. Wall, and R. H. Kardon Structure versus Function in Glaucoma: An Application of a Linear Model Invest. Ophthalmol. Vis. Sci., August 1, 2007; 48(8): 3662 - 3668. [Abstract] [Full Text] [PDF]

				C. K.-s. Leung, F. A. Medeiros, L. M. Zangwill, P. A. Sample, C. Bowd, D. Ng, C. Y. L. Cheung, D. S. C. Lam, and R. N. Weinreb American Chinese Glaucoma Imaging Study: A Comparison of the Optic Disc and Retinal Nerve Fiber Layer in Detecting Glaucomatous Damage Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2644 - 2652. [Abstract] [Full Text] [PDF]

				C J W Hudson, L S Kim, S A Hancock, I A Cunliffe, and J M Wild Some dissociating factors in the analysis of structural and functional progressive damage in open-angle glaucoma Br. J. Ophthalmol., May 1, 2007; 91(5): 624 - 628. [Abstract] [Full Text] [PDF]

				T. A. Mai, N. J. Reus, and H. G. Lemij Structure-Function Relationship Is Stronger with Enhanced Corneal Compensation than with Variable Corneal Compensation in Scanning Laser Polarimetry Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1651 - 1658. [Abstract] [Full Text] [PDF]

				J.-C. Tsai, P.-W. Lin, M.-C. Teng, and I.-C. Lai Longitudinal Changes in Retinal Nerve Fiber Layer Thickness after Acute Primary Angle Closure Measured with Optical Coherence Tomography Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1659 - 1664. [Abstract] [Full Text] [PDF]

				R. O. Duncan, P. A. Sample, R. N. Weinreb, C. Bowd, and L. M. Zangwill Retinotopic Organization of Primary Visual Cortex in Glaucoma: A Method for Comparing Cortical Function with Damage to the Optic Disk Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 733 - 744. [Abstract] [Full Text] [PDF]