IOVS The FASEB Journal
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2006;47:3242-3246.)
© 2006 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.05-1532
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lau, L.-I.
Right arrow Articles by Wei, Y.-H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lau, L.-I.
Right arrow Articles by Wei, Y.-H.

Association of the Y402H Polymorphism in Complement Factor H Gene and Neovascular Age-Related Macular Degeneration in Chinese Patients

Ling-Ing Lau,1,2,3 Shih-Jen Chen,2,3,4 Ching-Yu Cheng,1,2,3 May-Yung Yen,2,3 Fenq-Lih Lee,2,3 Ming-Wei Lin,5,6 Wen-Ming Hsu,2,3 and Yau-Huei Wei1,7

1From the Institute of Clinical Medicine and 3Departments of Ophthalmology, 5Family Medicine, and 7Biochemistry and Molecular Biology, School of Medicine, and the 4Center of Community Medicine, Public Health School, National Yang-Ming University, Taipei, Taiwan; and the 2Departments of Ophthalmology and 6Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan.

PURPOSE. Age-related macular degeneration (AMD), with its complex traits and multiple risk factors, is the leading cause of blindness in the elderly. A strong association between a coding variant, Y402H, in the complement factor H gene (CFH) and AMD has been recently identified in white patients. This study was conducted to investigate the association between the Y402H polymorphism in CFH and neovascular AMD in Chinese patients.

METHODS. One hundred sixty-three Chinese patients with neovascular AMD and 232 age-matched healthy controls were enrolled in the study. Genomic DNA from white blood cells was extracted. The Y402H polymorphism in CFH, with the substitution of T to C at nucleotide position 1277 in exon 9, was determined by polymerase chain reaction–restriction fragment length polymorphism analysis. The association between the genetic polymorphism and the disease was examined by {chi}2 test and logistic regression.

RESULTS. The frequency of the risk allele, 1277C, was 11.3% in AMD patients compared with 2.8% in controls (P < 0.00001). Genotype frequency differed significantly between the two groups (1277TT 81.0%, 1277TC 15.3%, and 1277CC 3.7% in the AMD group; 1277TT 94.4%, 1277TC 5.6%, and 1277CC 0% in the control group; P < 0.0001). The 1277C allele significantly increased the risk for neovascular AMD and had an odds ratio of 4.4 (95% confidence interval [95% CI], 2.3–8.5; P < 0.00001).

CONCLUSIONS. The allele frequency of Y402H polymorphism in CFH has an ethnic variation, with much lower 1277C frequency in Chinese than in white patients. Despite this, the polymorphism is significantly associated with neovascular AMD in the Chinese population.




This article has been cited by other articles:


Home page
 Br. J. Ophthalmol.Home page
P Cackett, W T Tay, T Aung, J J Wang, A Shankar, S M Saw, P Mitchell, and T Y Wong
Education, socio-economic status and age-related macular degeneration in Asians: the Singapore Malay Eye Study
Br. J. Ophthalmol., October 1, 2008; 92(10): 1312 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. K. Ng, L. J. Chen, D. T. L. Liu, P. O. S. Tam, W. M. Chan, K. Liu, Y. J. Hu, K. K. L. Chong, C. S. L. Lau, S. W. Y. Chiang, et al.
Multiple Gene Polymorphisms in the Complement Factor H Gene Are Associated with Exudative Age-Related Macular Degeneration in Chinese
Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3312 - 3317.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S.-J. Chen, C.-Y. Cheng, K.-L. Peng, A.-F. Li, W.-M. Hsu, J.-H. Liu, and P. Chou
Prevalence and Associated Risk Factors of Age-Related Macular Degeneration in an Elderly Chinese Population in Taiwan: The Shihpai Eye Study
Invest. Ophthalmol. Vis. Sci., July 1, 2008; 49(7): 3126 - 3133.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
K. Y. Lee, E. N. Vithana, R. Mathur, V. H. Yong, I. Y. Yeo, A. Thalamuthu, M.-W. Lee, A. H. Koh, M. C. Lim, A. C. How, et al.
Association Analysis of CFH, C2, BF, and HTRA1 Gene Polymorphisms in Chinese Patients with Polypoidal Choroidal Vasculopathy
Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2613 - 2619.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Hakobyan, C. L. Harris, A. Tortajada, E. Goicochea de Jorge, A. Garcia-Layana, P. Fernandez-Robredo, S. Rodriguez de Cordoba, and B. P. Morgan
Measurement of Factor H Variants in Plasma Using Variant-Specific Monoclonal Antibodies: Application to Assessing Risk of Age-Related Macular Degeneration
Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 1983 - 1990.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. R. Kim, J. H. Kang, O. W. Kwon, S. J. Lee, J. H. Oh, and H. S. Chin
Association between Complement Factor H Gene Polymorphisms and Neovascular Age-Related Macular Degeneration in Koreans
Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 2071 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. J. Ormsby, S. Ranganathan, J. C. Tong, K. M. Griggs, D. P. Dimasi, A. W. Hewitt, K. P. Burdon, J. E. Craig, J. Hoh, and D. L. Gordon
Functional and Structural Implications of the Complement Factor H Y402H Polymorphism Associated with Age-Related Macular Degeneration
Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 1763 - 1770.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
I Droz, I Mantel, A Ambresin, M Faouzi, D F Schorderet, and F L Munier
Genotype-phenotype correlation of age-related macular degeneration: influence of complement factor H polymorphism
Br. J. Ophthalmol., April 1, 2008; 92(4): 513 - 517.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Y.-Y. Tsai, J.-M. Lin, L. Wan, H.-J. Lin, Y. Tsai, C.-C. Lee, C.-H. Tsai, F.-J. Tsai, and S.-H. Tseng
Interleukin Gene Polymorphisms in Age-Related Macular Degeneration
Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 693 - 698.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
K. Mori, P. L. Gehlbach, S. Kabasawa, I. Kawasaki, M. Oosaki, H. Iizuka, S. Katayama, T. Awata, and S. Yoneya
Coding and Noncoding Variants in the CFH Gene and Cigarette Smoking Influence the Risk of Age-Related Macular Degeneration in a Japanese Population
Invest. Ophthalmol. Vis. Sci., November 1, 2007; 48(11): 5315 - 5319.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
J. S. Pulido, J. P. McConnell, L. M. Peterson, W. E. Highsmith, R. J. Lennon, S. C. Bryant, P. B. Berger, and V. Somers
Relationship Between Age-Related Macular Degeneration-Associated Variants of Complement Factor H and LOC387715 With Coronary Artery Disease
Mayo Clin. Proc., March 1, 2007; 82(3): 301 - 307.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Association for Research in Vision and Ophthalmology