HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Huynh, S. C. Articles by Mitchell, P. Search for Related Content PubMed PubMed Citation Articles by Huynh, S. C. Articles by Mitchell, P.

Distribution of Optic Disc Parameters Measured by OCT: Findings from a Population-Based Study of 6-Year-Old Australian Children

¹From the Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia; the ²Vision Co-operative Research Centre, School of Optometry, University of New South Wales, Sydney, Australia; and the ³Hamilton Glaucoma Center, University of California-San Diego, La Jolla, California.

PURPOSE. To study the distribution of optic disc, cup, and neural rim size by ocular and demographic variables in a population-based sample of 6-year-old children.

METHODS. The Sydney Childhood Eye Study examined 1765 of 2238 eligible 6-year-old children (78.9%) from 34 randomly selected Sydney schools during 2003 to 2004. Comprehensive standardized eye examination included cycloplegic autorefraction, optical biometry and "fast optic disc" scans performed using optical coherence tomography.

RESULTS. Scans of adequate quality were available for 1309 children (75% of participants), with 70% aged 6 years; 50.9% were boys. Mean (± SD) horizontal and vertical disc diameter and disc area was 1.53 ± 0.21 mm, 1.79 ± 0.28 mm, and 2.20 ± 0.39 mm², respectively. Corresponding cup dimensions were 0.70 ± 0.28 mm, 0.73 ± 0.27 mm, and 0.48 ± 0.32 mm². A definable optic cup was absent in 7.4%, 87% of whom were European white. Cup-to-disc diameter ratios were 0.46 ± 0.16 horizontally and 0.42 ± 0.15 vertically, whereas cup-to-disc area ratio was 0.22 ± 0.13. Mean ± SD neural rim area was 1.76 ± 0.44 mm² and increased with disc size (Pearson correlation = 0.68, P < 0.0001). Horizontal and vertical average nerve widths were 0.36 ± 0.05 and 0.28 ± 0.05 mm, respectively. In analyses adjusting for potential confounders, disc area increased significantly with axial length (P_trend < 0.0001) and refraction (P_trend = 0.02). Rim area increased only with axial length (P_trend = 0.01). There were no gender differences, except for average nerve width, marginally greater in boys. Most disc and cup dimensions were significantly larger in East-Asian than European white and Middle Eastern children.

CONCLUSIONS. Disc, cup, and neural rim parameters were generally normally distributed in this young population. Axial length appeared to be a stronger determinant of disc and rim size than refraction. Some ethnic but not gender differences were demonstrated for most parameters.

This article has been cited by other articles:

				M. A. El-Dairi, S. G. Asrani, L. B. Enyedi, and S. F. Freedman Optical Coherence Tomography in the Eyes of Normal Children Arch Ophthalmol, January 1, 2009; 127(1): 50 - 58. [Abstract] [Full Text] [PDF]

				S. C. Huynh, X. Y. Wang, G. Burlutsky, E. Rochtchina, F. Stapleton, and P. Mitchell Retinal and Optic Disc Findings in Adolescence: A Population-Based OCT Study Invest. Ophthalmol. Vis. Sci., October 1, 2008; 49(10): 4328 - 4335. [Abstract] [Full Text] [PDF]

				N. Cheung, S. Huynh, J. J. Wang, B. Taylor, F. M. A. Islam, S. M. Saw, T. Y. Wong, and P. Mitchell Relationships of Retinal Vessel Diameters with Optic Disc, Macular and Retinal Nerve Fiber Layer Parameters in 6-Year-Old Children Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2403 - 2408. [Abstract] [Full Text] [PDF]