IOVS Journal of Applied Physiology
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(Investigative Ophthalmology and Visual Science. 2006;47:3968-3974.)
© 2006 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.05-1345
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Effect of Subconjunctivally Injected, Liposome-Bound, Low-Molecular-Weight Heparin on the Absorption Rate of Subconjunctival Hemorrhage in Rabbits

Jun-Woong Moon,1,2 Yun-Kyoung Song,2,3,4 Jun-Pil Jee,3 Chong-Kook Kim,3 Ho-Kyung Choung,5 and Jeong-Min Hwang1,6

1From the Department of Ophthalmology, Seoul National University College of Medicine, Artificial Eye Center of Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; 3Laboratory of Excellency for Drug and Gene Delivery, College of Pharmacy, Seoul National University, Seoul, Korea; 4Test and Analytical Laboratory, Korea Food and Drug Administration, Seoul, Korea; the 5Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul, Korea; and the 6Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea.

PURPOSE. To investigate the effect of subconjunctival injection of liposome-bound, low-molecular-weight heparin (LMWH) on the absorption rate of subconjunctival hemorrhages.

METHODS. Subconjunctival hemorrhages were induced in both eyes of 30 rabbits by the subconjunctival injection of 0.1 mL of autologous blood from auricular marginal veins. After 8 hours, randomized subconjunctival injections of one of three materials were made: 5 IU/mL liposome-bound LMWH (0.1 mL) in 18 eyes (group A), only liposomes (0.1 mL) in 14 eyes (group B), the free form of LMWH (5 IU/mL, 0.1 mL) in 14 eyes (group C), or no injection in 14 eyes (group D). Subconjunctival hemorrhages were photographed with a digital camera at 8, 24, 48, 72, 96, and 120 hours after induction of subconjunctival hemorrhages, sized with an image analyzer, and compared between groups.

RESULTS. Subconjunctival hemorrhages were absorbed faster in group A (liposome-bound LMWH injected) than in with group B (liposome injected). Comparison of groups A and C (free LMWH injected) showed statistical differences in the absorption rates at 96 and 120 hours except at 24, 48, and 72 hours. The mean elapsed time for the complete resorption of subconjunctival hemorrhages was shortest in group A among four groups, whereas group B and the control showed no significant differences. The ocular and systemic absorption of LMWH were significantly lower after injection of the liposome-bound than the free form.

CONCLUSIONS. The subconjunctival injection of liposome-bound LMWH appears to enhance subconjunctival hemorrhage absorption in rabbits.






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