IOVS Journal of Neurophysiology
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(Investigative Ophthalmology and Visual Science. 2007;48:4924-4929.)
© 2007 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-0572
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Genetic Mapping of Myopia Susceptibility Loci

Maria Schäche,1,2 Andrea J. Richardson,1,2 Kelly K. Pertile,1,2 Mohamed Dirani,1,2 Katrina Scurrah,3,4 and Paul N. Baird1,2

1From the Centre for Eye Research Australia, the 3Department of Physiology, and the 4Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia; and the 2Vision Cooperative Research Centre, Sydney, Australia.

PURPOSE. Myopia (short sightedness) is a complex trait influenced by as yet unidentified genetic factors. To date, there have been four myopia susceptibility loci (MYP7 to -10) identified in twin studies, but these are yet to be independently verified. In an independent yet ethnically and phenotypically similar twin cohort, linkage to these chromosomal regions was sought.

METHODS. Participants were 223 dizygotic twin pairs from the Australian Twin Registry who were assessed for evidence of linkage, by using polymorphic microsatellite markers spanning MYP7-10. Data were analyzed by using Haseman-Elston regression analysis.

RESULTS. No evidence of linkage of myopia or its underlying biological components such as eye length to the MYP7-10 regions was found in this twin cohort.

CONCLUSIONS. This is the first study to assess for linkage in a secondary myopia twin cohort and highlights the problems associated with applying linkage results from complex traits to the other populations.






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