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(Investigative Ophthalmology and Visual Science. 2007;48:5207-5211.)
© 2007 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.06-1199
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A Comparison of Macular Structure Imaged by Optical Coherence Tomography in Preterm and Full-Term Children

Monika Ecsedy,1 Anna Szamosi,1 Cecilia Karkó,2 Laszlo Zubovics,3 Balazs Varsányi,1 Janos Németh,1 and Zsuzsa Récsán1

1From the Department of Ophthalmology, Semmelweis University, Budapest, Hungary; the 2Department of Ophthalmology, St. Borbala County Hospital, Tatabanya, Hungary; and the 3Neonatal Care Unit, Schöpf-Merei County Hospital, Budapest, Hungary.

PURPOSE. Macular anatomic abnormalities were examined by optical coherence tomography (OCT) imaging in premature children and compared with those of full-term children.

METHODS. In a prospective case–control study, premature patients 7 to 14 years of age were divided into three groups (group I, laser-treated retinopathy of prematurity [ROP]; group II, spontaneously regressed ROP; group III, no ROP), and age-matched children (group IV). All the eligible 74 eyes had normal-appearing posterior pole, myopia ≤3 D, and best corrected visual acuity 1.0. When both eyes of a subject were eligible for the study, one eye was randomly selected (10 eyes of 10 children in each group). Retinal thicknesses of the macula measured by OCT3 were compared. The correlation between central foveal thickness and prematurity (gestational age at birth ≤ 30 weeks; birth weight ≤ 1250 g) or ROP was determined.

RESULTS. The mean foveal and central retinal thicknesses decreased significantly in group I (laser-treated ROP) and group IV (term birth). Significant differences in central retinal thickness were found between the premature groups and full-term children (Mann-Whitney U test). The cutoff point of central retinal thickness, determined by receiver operating characteristic curve was 209 µm. The general estimating equation model statistics found a significant effect of ROP severity (P = 0.003), P value for the category of prematurity was 0.063.

CONCLUSIONS. The central retinal thickness was significantly higher in the preterm groups than in the full-term group. This subtle macular modification may be related mainly to ROP. Prematurity had only a marginally significant role.






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