IOVS Physiological Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2007;48:733-744.)
© 2007 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.06-0773
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duncan, R. O.
Right arrow Articles by Zangwill, L. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duncan, R. O.
Right arrow Articles by Zangwill, L. M.

Retinotopic Organization of Primary Visual Cortex in Glaucoma: A Method for Comparing Cortical Function with Damage to the Optic Disk

Robert O. Duncan, Pamela A. Sample, Robert N. Weinreb, Christopher Bowd, and Linda M. Zangwill

From the Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, California.

PURPOSE. To demonstrate that the relationship between the functional organization of primary visual cortex (V1) and damage to the optic disc in humans with primary open-angle glaucoma (POAG) can be measured using a novel method for projecting scotomas onto the flattened cortical representation.

METHODS. Six subjects participated in this functional magnetic resonance imaging (fMRI) experiment. Structural damage to the optic disc and the retinal nerve fiber layer (RNFL) was measured by three techniques: scanning laser polarimetry (GDx ECC; Carl Zeiss Meditec, Dublin, CA), confocal scanning laser ophthalmoscopy (HRT II; Heidelberg Engineering, Heidelberg, Germany), and optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc.). Cortical activity for viewing through the glaucomatous versus fellow eye was compared by alternately presenting each eye with a contrast-reversing checkerboard pattern. The resultant fMRI response was compared to interocular differences in RNFL or mean height contour for analogous regions of the visual field.

RESULTS. fMRI responses to visual stimulation were related to differences in RNFL thickness or mean height contour between eyes. The correlation between fMRI responses and measurements of optic disc damage for OCT (RNFL), HRT (mean height contour), and GDx (RNFL) were r = 0.90 (P = 0.02), r = 0.84 (P = 0.04), and r = 0.79 (P = 0.063), respectively. The probability of observing all three correlations by chance was low (P = 0.0003).

CONCLUSIONS. Cortical activity in human V1 was altered in these six POAG subjects in a manner consistent with damage to the optic disc. fMRI is a possible means for quantifying cortical neurodegeneration in POAG.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the Association for Research in Vision and Ophthalmology