IOVS JNNP
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 2007;48:1913-1917.)
© 2007 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.06-1075
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lagrèze, W. A.
Right arrow Articles by Bley, T. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lagrèze, W. A.
Right arrow Articles by Bley, T. A.

Morphometry of the Retrobulbar Human Optic Nerve: Comparison between Conventional Sonography and Ultrafast Magnetic Resonance Sequences

Wolf A. Lagrèze,1 Alexander Lazzaro,1 Matthias Weigel,2 Hans-Christian Hansen,3 Jürgen Hennig,2 and Thorsten A. Bley2

1From the Departments of Ophthalmology and 2Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany; and the 3Department of Neurology and Psychiatry, Friedrich-Ebert-Krankenhaus, Neumünster, Germany.

PURPOSE. To compare different methods for quantification of optic nerve and nerve sheath diameter. To apply a novel magnetic resonance protocol using half-Fourier acquired single-shot turbo spin-echo (HASTE) sequences to analyze optic nerve dimensions.

METHODS. Measurements were taken in right eyes of 33 subjects whose median age was 25 years. A-scan ultrasonography was repeated three times in straight gaze. B-scan ultrasonography was repeated three times in straight gaze and abduction. HASTE sequences were applied in straight gaze, analyzed twice by two different radiologists, and completely repeated in a subset of 10 subjects; 95% confidence intervals and coefficients of variation were calculated.

RESULTS. HASTE sequences yielded high contrast between cerebrospinal fluid and optic nerve parenchyma. Acquisition time for each sequence was 1.5 seconds per slice. Optic nerve diameters decreased from 3.23 mm at 5 mm to 2.67 mm at 15 mm behind the eye. Sheath diameters decreased from 5.72 mm to 3.98 mm. A- and B-scan ultrasonography yielded significantly smaller diameters. For HASTE sequences, the coefficients of variation ranged from 2% to 7% and were significantly smaller than those obtained with ultrasonographic measurements (9%–13%).

CONCLUSIONS. The precision of magnetic resonance imaging exceeds that of ultrasonographic methods for determining optic nerve and nerve sheath diameters. HASTE sequences appear particularly appropriate for investigating the retrobulbar optic nerve complex and may be useful in future studies quantifying axonal loss within the optic nerve.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the Association for Research in Vision and Ophthalmology