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(Investigative Ophthalmology and Visual Science. 2007;48:2037-2042.)
© 2007 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.06-0957
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Photo Cross-linkable Biodendrimers as Ophthalmic Adhesives for Central Lacerations and Penetrating Keratoplasties

Lovorka Degoricija,1,2 C. Starck Johnson,3 Michel Wathier,1,2 Terry Kim,3 and Mark W. Grinstaff1,2

1From the Departments of Chemistry and 2Biomedical Engineering, Boston University, Boston, Massachusetts; and the 3Duke University Eye Center, Durham, North Carolina.

PURPOSE. Biodendrimer-based hydrogel adhesives were derived from biocompatible building blocks and poly(ethylene glycol) of 3,400, 10,000 and 20,000 g/mole. The leaking pressures were determined for these adhesives when used to seal 4.1-mm central lacerations and penetrating keratoplasties (PKPs) in enucleated porcine eyes.

METHODS. Three biodendrimers, ([G1]-PGLSA-MA)2-PEG3,400, ([G1]-PGLSA-MA)2-PEG10,000, and ([G1]-PGLSA-MA)2-PEG20,000, at a range of weight percents were each photo cross-linked in the presence of a photo-initiator to form a hydrated network. These biodendrimer-based adhesives were applied directly to a 4.1-mm linear central laceration. In a PKP, the corneal button was initially secured with 8 or 16 sutures and then sealed with the adhesive.

RESULTS. For the 4.1-mm central lacerations, the ([G1]-PGLSA-MA)2-PEG3,400 at 20% and 40% wt/vol, the ([G1]-PGLSA-MA)2-PEG10,000 at 10 and 20% wt/vol, and the ([G1]-PGLSA-MA)2-PEG20,000 at 20% wt/vol held to leaking pressures above 200 mm Hg. In the autograft with 16 sutures, the 20% wt/vol of the ([G1]-PGLSA-MA)2-PEG3,400, ([G1]-PGLSA-MA)2-PEG10,000, and ([G1]-PGLSA-MA)2-PEG20,000 held to a pressure at or above 100 mm Hg. In the autograft with eight sutures, the ([G1]-PGLSA-MA)2-PEG10,000 and ([G1]-PGLSA-MA)2-PEG20,000 formulations at 20% wt/vol held to leaking pressures of 85 ± 22 and 80 ± 30 mm Hg, respectively.

CONCLUSIONS. The 10% wt/vol ([G1]-PGLSA-MA)2-PEG10,000 formulation withheld leaking pressures above 200 mm Hg when used to secure a 4.1 mm central laceration. The 20% wt/vol ([G1]-PGLSA-MA)2-PEG10,000 and ([G1]-PGLSA-MA)2-PEG20,000 formulations, with 8 or 16 sutures, secured the PKP well above normal IOP. Biodendrimer-based adhesives are of potential use for repairing corneal wounds.






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