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Acute Superior Oblique Palsy in Monkeys: III. Relationship to Listing’s Law

¹From the Departments of Neurology, ²Ophthalmology, and ³Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; and the ⁴National Eye Institute, National Institutes of Health, Bethesda, Maryland.

PURPOSE. To investigate the three-dimensional orientation of the eye and its relationship to Listing’s Law in monkeys with acute acquired superior oblique palsy (SOP).

METHODS. The trochlear nerve was severed intracranially in two rhesus monkeys. Three-axis eye movements (horizontal, vertical, and torsion) were measured with binocular, dual search coils during fixation of targets in a 40° x 40° grid. Rotation vectors were calculated, and Listing’s plane (LP) was determined by a least-squares planar fit of eye torsion as a function of horizontal and vertical position.

RESULTS. The main findings were: (1) In the paretic eye, there was an immediate and sustained rotation of the orientation plane by approximately 25° in the temporal direction; (2) the thickness of LP, defined as the torsional standard deviation (SD), increased little (by 0.13° in M1 and 0.08° in M2) after SOP, and (3) the SD of intrasaccadic torsion was slightly greater than that during fixation, but there was no change after SOP.

CONCLUSIONS. Acute SOP in rhesus monkeys leads to a temporal rotation of LP. This is consistent with a relatively increased extorsion in down gaze due to a loss of normal intorsion by the superior oblique muscle. The SD of torsion increased by only a small amount, implying that the validity of Listing’s Law is not affected much by complete SOP, despite the large change in the orientation of LP.

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