IOVS AJP: Gastrointestinal and Liver Physiology
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(Investigative Ophthalmology and Visual Science. 2008;49:133-138.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-0762
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Serial Measurements of Higher-Order Aberrations after Blinking in Patients with Dry Eye

Shizuka Koh,1 Naoyuki Maeda,1 Yoko Hirohara,2 Toshifumi Mihashi,2 Kenichiro Bessho,1,3 Yuichi Hori,1 Tomoyuki Inoue,1 Hitoshi Watanabe,1 Takashi Fujikado,1,3 and Yasuo Tano1

1From the Department of Ophthalmology, Osaka University Medical School, Suita, Japan; the 2Technical Research Institute, Topcon Corporation, Tokyo, Japan; and the 3Department of Applied Visual Science, Osaka University Medical School, Suita, Japan.

PURPOSE. To study the sequential postblink changes in ocular higher-order aberrations (HOAs) in patients with dry eye.

METHODS. A wavefront sensor was used to measure HOAs sequentially for 30 seconds in 20 eyes of 20 patients with dry eye. The 20 eyes were classified into two groups, with or without superficial punctate keratopathy (SPK) in the central cornea. During the measurement, subjects were required to blink every 10 seconds. The aberration data were analyzed in the central 4-mm diameter for coma-like, spherical-like, and total HOAs up to sixth-order Zernike polynomials. Total HOAs, as well as fluctuation index (FI) and stability index (SI) of the total HOAs over time were compared between the two groups. The sequential changes in coma-like aberration, spherical-like aberration, and total HOAs were also investigated.

RESULTS. The total ocular HOAs were significantly (P = 0.001) greater in dry eyes with central SPK than in dry eyes without central SPK. The sequential pattern of the total ocular HOAs had higher initial and consistently higher values in dry eyes with central SPK, whereas that of dry eyes without central SPK showed consistently lower total HOAs that were similar to the pattern of normal eyes.

CONCLUSIONS. Increased HOAs in dry eye at least partially result from SPK above the optical zone. The low tear volume in dry eye may not cause sequential increases in HOAs after blinking. Sequential measurement of HOAs may be useful for evaluating the sequential changes in optical quality in patients with dry eye.






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Copyright © 2008 by the Association for Research in Vision and Ophthalmology