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Originally published In Press as doi:10.1167/iovs.08-1749 on June 27, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:4340-4346.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-1749
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The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project

Traci E. Clemons,1 Mark C. Gillies,2 Emily Y. Chew,3 Alan C. Bird,4 Tunde Peto,4 Maria Figueroa,1 Molly W. Harrington1 for the MacTel Research Group5

1From the The EMMES Corporation, Rockville, Maryland; the 2Department of Clinical Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia; the 3National Eye Institute, Bethesda, Maryland; the 4Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom.

PURPOSE. To describe vision-targeted health-related quality of life (HR-QOL), measured with the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) in a cohort of patients with macular telangiectasia (MacTel) type 2 and to evaluate the relationship between visual acuity and NEI-VFQ-25 scores.

METHODS. This was an analysis of cross-sectional baseline data from a longitudinal natural history study. Patients with MacTel type 2 were enrolled in the Natural History Study of The Macular Telangiectasia Project (The MacTel Project). NEI-VFQ-25 were completed at enrollment. Linear correlation and regression analyses were used to relate baseline NEI-VFQ-25 overall and subscale scores to visual acuity.

RESULTS. Participants reported lower vision-related functioning measured by the NEI-VFQ-25 in most of the domains measured by the NEI VFQ compared with that of a normal reference group (P < 0.001 for all domains except color vision). Visual acuity was found to be associated with the NEI-VFQ-25 in many of the domains measuring degree of difficulty with common visual activities.

CONCLUSIONS. This is the first cross-sectional cohort study to assess vision targeted HR-QOL in patients with MacTel type 2. Patients with MacTel type 2 reported markedly reduced visual functioning compared to reports of a normal reference group. These findings provide support to the use of the NEI-VFQ-25 in patients with MacTel type 2 to measure the effect of disease and potential therapies on vision-targeted HR-QOL.






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