IOVS Molecular Human Reproduction
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1167/iovs.08-1678 on July 3, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:4707-4711.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.08-1678
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
iovs.08-1678v1
49/11/4707    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wickremasinghe, S. S.
Right arrow Articles by Wong, T. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wickremasinghe, S. S.
Right arrow Articles by Wong, T. Y.

Retinal Vascular Caliber Changes after Intravitreal Triamcinolone Treatment for Diabetic Macular Edema

Sanjeewa S. Wickremasinghe,1,2 Sophie L. Rogers,1 Mark C. Gillies,3 Meidong Zhu,3 and Tien Y. Wong1,2,4

1From the Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; 2Royal Victorian Eye and Ear Hospital, Melbourne, Australia; 3Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia; and the 4Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

PURPOSE. To describe the changes in retinal vascular caliber in response to a single injection of intravitreal triamcinolone (IVTA) in patients with refractory diabetic macular edema.

METHODS. Prospective data from a randomized clinical trial were used. The effects of IVTA versus sham injections in patients with refractory diabetic macular edema were evaluated in a randomized clinical trial involving 69 eyes of 43 patients. Of these, 28 eyes (15 IVTA and 13 sham) of 21 patients had gradable retinal photographs at the baseline and 3-month follow-up visit for analysis in the present study. Retinal vascular caliber was measured from digital fundus photographs and summarized as central retinal artery (CRAE) and vein (CRVE) equivalents in all eyes at baseline and at the 3-month follow-up visit.

RESULTS. Over the 3 months of the study, there was a significant reduction compared to baseline in retinal arteriolar (147.8 µm vs. 140.0 µm, P = 0.047) and venular (219.5 µm vs. 198 µm, P = 0.039) caliber in eyes treated with IVTA. There was no change in retinal arteriolar (139.9 µm vs. 139.2 µm, P = 0.878) or venular (220.3 µm vs. 217.6 µm, P = 0.534) caliber in those treated with sham injections.

CONCLUSIONS. IVTA has a significant narrowing effect on both retinal arteriolar and venular diameter in eyes with diabetic macular edema (ClinicalTrials.gov number, NCT00148330).






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the Association for Research in Vision and Ophthalmology