IOVS Advertisement
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1167/iovs.08-2134 on June 27, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:4729-4737.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-2134
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
iovs.08-2134v1
49/11/4729    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nakashizuka, H.
Right arrow Articles by Yuzawa, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakashizuka, H.
Right arrow Articles by Yuzawa, M.

Clinicopathologic Findings in Polypoidal Choroidal Vasculopathy

Hiroyuki Nakashizuka,1 Masako Mitsumata,2 Shigekuni Okisaka,3 Hiroyuki Shimada,1 Akiyuki Kawamura,1 Ryusaburo Mori,1 and Mitsuko Yuzawa1

1From the Division of Ophthalmology, Department of Visual Science, and the 2Division of Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; and the 3Laboratory of Ophthalmic Pathology Education, Tokyo, Japan.

PURPOSE. To elucidate the pathogenic mechanism of polypoidal choroidal vasculopathy (PCV) based on histopathologic findings.

METHODS. Specimens obtained by surgical excision of PCV from five eyes of five patients (mean age, 75.6 ± 3.1 years) were studied histopathologically. Immunohistochemical studies were also performed to identify CD34, vascular endothelial growth factor (VEGF), CD68, {alpha}-smooth muscle actin ({alpha}-SMA) and hypoxia-inducible factor (HIF)-1{alpha}.

RESULTS. Hyalinization of choroidal vessels and massive exudation of fibrin and blood plasma were observed in all the specimens of PCV lesions. Some blood vessels were located above the RPE in two of the five eyes. Immunohistochemically, CD68-positive cells were detected around the hyalinized vessels. There were no {alpha}-SMA-positive cells in the vessels of PCV. CD34 staining showed endothelial discontinuity. Vascular endothelial cells within the PCV specimens were negative for VEGF. HIF-1{alpha} positive inflammatory cells were located in the stroma of specimens.

CONCLUSIONS. Hyalinization of choroidal vessels, like arteriosclerosis, is characteristic of PCV.




This article has been cited by other articles:


Home page
 Br J OphthalmolHome page
P. Ruamviboonsuk, M. Tadarati, S. Vanichvaranont, P. Hanutsaha, and N. Pokawattana
Photodynamic therapy combined with ranibizumab for polypoidal choroidal vasculopathy: results of a 1-year preliminary study
Br J Ophthalmol, August 1, 2010; 94(8): 1045 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C.-C. Hu, J.-D. Ho, and H.-C. Lin
Neovascular Age-Related Macular Degeneration and the Risk of Stroke: A 5-Year Population-Based Follow-Up Study
Stroke, April 1, 2010; 41(4): 613 - 617.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the Association for Research in Vision and Ophthalmology