IOVS Journal of Neurophysiology
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Originally published In Press as doi:10.1167/iovs.08-1694 on August 15, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:5340-5345.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.08-1694
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Slow-Releasing Paclitaxel in Polytetrafluoroethylene/Polylactide-co-glycolide Laminate Delays Adjustment after Strabismus Surgery in Rabbit Model

Ho-Kyung Choung,1,2 Su-Eon Jin,2,3 Min Joung Lee,4 Chong-Kook Kim,3 and Jeong-Min Hwang5

1From the Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Boramae Hospital, Seoul, Korea; 3Laboratory of Excellence for Drug and Gene Delivery, College of Pharmacy, Seoul National University, Seoul, Korea; 4Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea; and 5Department of Ophthalmology, College of Medicine Seoul National University, Seoul National University Bundang Hospital, Seongnam, Korea.

PURPOSE. To determine the usefulness of slow-releasing paclitaxelin polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery.

METHODS. A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing paclitaxel, PTFE alone, or physiologic saline was applied beneath and over the SRM in the PTFE/PLGA-paclitaxel group (group paclitaxel), the PTFE group (group PTFE), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM at 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated.

RESULTS. In the control group, adjustment was impossible in any eye at 3 or 5 weeks after surgery. In group PTFE, adjustment was possible in 5 of 8 eyes at 3 weeks after surgery and in 5 of 10 eyes at 5 weeks after surgery. In group paclitaxel, adjustment was possible in 6 of 9 eyes and in 7 of 7 eyes at 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group paclitaxel and the control group at 3 and 5 weeks after surgery (P = 0.016 and P = 0.001, respectively). A significant difference was observed between group paclitaxel and the control group (P = 0.003) in terms of adhesion between SRMs and sclera 5 weeks after surgery.

CONCLUSIONS. Slow-releasing paclitaxel in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.






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