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Originally published In Press as doi:10.1167/iovs.08-2142 on August 21, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:5397-5402.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.08-2142
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Evidence of Retinal Vascular Narrowing in Glaucomatous Eyes in an Asian Population

Nishani Amerasinghe,1,2 Tin Aung,1,2 Ning Cheung,3 Chee Weng Fong,4 Jie Jin Wang,3,5 Paul Mitchell,5 Seang-Mei Saw,1,2,6 and Tien Yin Wong1,2,3

1From the Singapore National Eye Centre, Singapore; the 2Singapore Eye Research Institute and the 6Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; the 3Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, VC, Australia; the 4Epidemiology and Disease Control Division, Ministry of Health, Singapore; and the 5Centre for Vision Research, University of Sydney, Sydney, NSW, Australia.

PURPOSE. To examine the relationship between retinal vascular caliber and glaucoma in an Asian population.

METHODS. A population-based, cross-sectional study of 3019 persons of Asian Malay ethnicity aged 40 to 80 years residing in Singapore. All participants had dilated digital retinal photographs taken of both eyes. From these, retinal vascular caliber was measured with a computer-based technique according to a standardized protocol. Glaucoma was diagnosed based on the International Society of Geographic and Epidemiologic Ophthalmology classification and included people with glaucomatous optic neuropathy and compatible visual field loss.

RESULTS. There were 127 (4.2%) participants with glaucoma. Mean retinal arteriolar and venular calibers were significantly narrower in persons with than in those without glaucoma (136.4 µm vs. 139.7 µm, P = 0.02 and 209.2 µm vs. 219.7 µm, P < 0.001, respectively). After adjusting for age, sex, smoking, IOP, and other vascular risk factors, persons with narrower retinal arteriolar and venular caliber were more likely to have glaucoma (odds ratio [OR], 1.29; 95% confidence interval [CI], 1.07–1.56 and OR, 1.49; 95% CI, 1.24–1.79, for each SD reduction in arteriolar and venular caliber, respectively) and a vertical cup-to-disc ratio ≥ 0.7 (OR, 1.35; 95% CI, 1.12–1.63 and OR, 1.65; 95% CI, 1.38–1.98, respectively). Retinal vascular caliber was not associated with intraocular pressure.

CONCLUSIONS. These findings support an association of narrower retinal arteriolar and venular caliber changes with glaucomatous optic neuropathy, independent of intraocular pressure.






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