IOVS AJP: Endocrinology and Metabolism
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(Investigative Ophthalmology and Visual Science. 2008;49:807-813.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-0994
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Local Neuroretinal Function during Acute Hypoxia in Healthy Older People

Beatrix Feigl,1,2 Ian B. Stewart,1,3 Brian Brown,1,2 and Andrew J. Zele1,2

1From the Institute of Health and Biomedical Innovation, 2School of Optometry, and the 3School of Human Movement Studies, Queensland University of Technology, Brisbane, Queensland, Australia.

PURPOSE. To measure the effect of acute, mild, systemic hypoxia on neuroretinal function in two different age groups.

METHODS. The slow-flash paradigm of the multifocal electroretinogram (mfERG) was measured in two different oxygenation levels. Twelve participants of two age groups (28 ± 4 and 55 ± 5 years) breathed room air (normoxia) or 12% oxygen (hypoxia).

RESULTS. During normoxia (SaO2 = 98%) there was a significantly different effect between the younger and older participants on the mfERG positive waveform components (N1P1 amplitudes and P1 implicit times; P < 0.001). Hypoxia (SaO2 = 90%) significantly decreased N1P1 response density amplitudes in the central retinal field in both groups, with a larger effect in the older group (P < 0.001). There was no significant change in function of the cellular generators of oscillatory potentials (OPs).

CONCLUSION. The results extend recent findings by showing a greater effect of hypoxia on ON- and OFF-bipolar cell function in healthy older persons than in younger persons, but no effect on OPs during moderate acute hypoxia in either age group.






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