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Originally published In Press as doi:10.1167/iovs.07-1454 on March 24, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:2526-2530.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-1454
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Abnormal Cellular Reactivity to Microbial Antigens in Patients with Uveitis

Grégoire Jacques Noël Cozon,1,2 Florentin Martial Mbitikon-Kobo,1,2 Fathi Fatoohi,1,2 Myriam Spire,3 Jean-Daniel Grange,3 and Laurent Kodjikian3

1From the Laboratoire d’Immunologie and the 3Service d’Ophtalmologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France; and 2INSERM U851, Université Lyon 1, Lyon, France.

PURPOSE. The purpose of the present study was to evaluate the cellular response to microbial antigens in patients with idiopathic uveitis.

METHODS. Blood lymphocytes from 31 patients with uveitis and 24 healthy controls were cultivated with microbial antigens and analyzed by flow cytometry after staining with monoclonal antibodies against CD3, CD4, and activation markers CD69 and CD25.

RESULTS. Although no difference was noted in circulating lymphocytes, the activation of T cells, detected with CD69, was higher in 24-hour blood culture from uveitis patients with Candida albicans antigen (Ca-Ag) than from controls, especially in posterior uveitis and panuveitis. Moreover, late response, detected with CD25, to different microbial antigens was higher in patient with uveitis.

CONCLUSIONS. Such results suggest the role of Ca-Ag and microbial antigens in the pathogenic mechanisms of idiopathic uveitis.






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