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Originally published In Press as doi:10.1167/iovs.08-1835 on April 11, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:3121-3125.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.08-1835
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Focal Macular Electroretinograms in Eyes with Wet-type Age-Related Macular Degeneration

Hiroaki Nishihara, Mineo Kondo, Kohei Ishikawa, Tadasu Sugita, Chang-Hua Piao, Yoshiharu Nakamura, and Hiroko Terasaki

From the Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

PURPOSE. To study the properties of the focal macular electroretinograms (fmERGs) in eyes with untreated wet-type age-related macular degeneration (AMD).

METHODS. fmERGs were recorded from 157 eyes of 157 consecutive patients with untreated wet-type AMD (113 men, 44 women; age, 71.3 ± 8.0 years). The fmERGs were recorded under direct fundus observation using a modified infrared fundus camera and a 15° stimulus spot. Amplitudes and implicit times of the fmERGs recorded from the AMD patients were compared with those from 21 age-similar healthy controls.

RESULTS. The amplitudes of fmERGs in the AMD patients were significantly smaller (P < 0.001) and the implicit times were significantly longer (P < 0.001) than the corresponding values in the control eyes. There was a significant correlation between amplitude and implicit time of the fmERG and visual acuity (logMAR), but the degree of correlation was weak. The difference in the b/a amplitude ratio between the AMD patients and healthy controls was not significant.

CONCLUSIONS. The significant reduction in amplitude and the severe delay in implicit times of a- and b-waves of the fmERGs indicated significant functional alterations in the inner and the outer retinal layers of the macular area of eyes with wet-type AMD.






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