IOVS Journal of Pharmacology and Experimental Therapeutics
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Originally published In Press as doi:10.1167/iovs.08-1768 on April 4, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:3283-3288.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.08-1768
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Increasing Incidence of Ophthalmic Lymphoma in Denmark from 1980 to 2005

Lene D. Sjö,1 Elisabeth Ralfkiaer,2 Jan U. Prause,1 Jorgen H. Petersen,3 Jakob Madsen,4 Niels T. Pedersen,5 and Steffen Heegaard1

1From the Eye Pathology Institute, Department of Neuroscience and Pharmacology, and the 3Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark; the 2Department of Pathology, Rigshospitalet, Copenhagen, Denmark; the 4Department of Hematology, Aalborg Hospital, University of Aarhus, Aarhus, Denmark; and the 5Department of Pathology, Odense University Hospital, Odense, Denmark.

PURPOSE. To evaluate patient characteristics and incidence of ophthalmic lymphoma in Denmark during the period 1980 to 2005.

METHODS. All patients in Denmark with a diagnosis of ophthalmic lymphoma during the period 1980 to 2005 were retrieved from three different population-based registries. Specimens from all patients were collected and reclassified according to the World Health Organization (WHO) classification system. Incidence rates were calculated by using Poisson regression models.

RESULTS. A total of 228 patients with a histologically verified diagnosis of ophthalmic lymphoma were included. There was an equal distribution of males and females. The most frequent lymphoma subtype was extranodal marginal zone B-cell lymphoma (MALT [mucosa-associated lymphoid tissue] lymphoma, 55.5%) and most cases were located in the orbit (56.8%). High-grade lymphoma subtypes were found more frequently in males than in females. Incidence rates were highly dependent on the patient’s age. For all ages, a statistically significant annual average increase of 3.4% during the 26-year period was found. This increase was primarily due to a rise in the incidence of MALT lymphoma.

CONCLUSIONS. In the Danish population ophthalmic lymphoma consists primarily of orbital MALT lymphoma. Although it is a rare disease in mostly elderly patients, the incidence of ophthalmic lymphoma is increasing at a rapid pace.




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L. D. Sjo, S. Heegaard, J. U. Prause, B. L. Petersen, S. Pedersen, and E. Ralfkiaer
Extranodal Marginal Zone Lymphoma in the Ocular Region: Clinical, Immunophenotypical, and Cytogenetical Characteristics
Invest. Ophthalmol. Vis. Sci., February 1, 2009; 50(2): 516 - 522.
[Abstract] [Full Text] [PDF]


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