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Originally published In Press as doi:10.1167/iovs.07-1477 on April 11, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:3469-3474.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-1477
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Anterior Chamber Angle Measurement with Anterior Segment Optical Coherence Tomography: A Comparison between Slit Lamp OCT and Visante OCT

Christopher Kai-shun Leung,1,2 Haitao Li,1 Robert Neal Weinreb,2 Jing Liu,1 Carol Yim Lui Cheung,1 Ricky Yiu Kwong Lai,1 Chi Pui Pang,1 and Dennis Shun Chiu Lam1

1From the Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China; and the 2Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, California.

PURPOSE. To compare anterior chamber angle measurements obtained from two anterior segment optical coherence tomography (OCT) instruments and to evaluate their agreements and interobserver reproducibility.

METHODS. Forty-nine eyes from 49 healthy normal subjects were studied. The anterior chamber angle was imaged with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and the slit lamp OCT (SLOCT, Heidelberg Engineering, GmbH, Dossenheim, Germany) on one randomly selected eye in each subject and measured by two independent observers. The angle-opening distance (AOD 500), the trabecular–iris angle (TIA 500), and the trabecular–iris space area (TISA 500) at the nasal and temporal angles were measured. The agreements between SLOCT and Visante OCT measurements and the interobserver reproducibility were evaluated.

RESULTS. The mean nasal/temporal anterior chamber angles measured by Visante OCT and SLOCT were 527 ± 249/572 ± 275 µm (AOD), 0.180 ± 0.091/0.193 ± 0.102 mm2 (TISA), and 38.1 ± 12.3/39.6 ± 13.2° (TIA); and 534 ± 234/628 ± 254 µm (AOD), 0.191 ± 0.089/0.217 ± 0.093 mm2(TISA), and 37.8 ± 10.1/40.6 ± 10.7° (TIA), respectively. No significant difference was found between Visante OCT and SLOCT measurements except the temporal TISA (P = 0.034). The interobserver coefficient of variation ranged between 4.4% and 7.8% for Visante OCT and 4.9% and 7.0% for SLOCT. The spans of 95% limits of agreement of the nasal/temporal angle measurements between Visante OCT and SLOCT were 437/531 mm2, 0.174/0.186 mm2, and 25.3/28.0° for AOD, TISA, and TIA, respectively.

CONCLUSIONS. Although Visante OCT and SLOCT demonstrate high interobserver reproducibility for anterior chamber angle measurements, their agreement was poor.




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