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Originally published In Press as doi:10.1167/iovs.07-1168 on March 7, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:3499-3502.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-1168
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Aqueous Humor Levels of Vascular Endothelial Growth Factor in Retinitis Pigmentosa

David Salom,1 Manuel Diaz-Llopis,1,2,3 Salvador García-Delpech,1 Patricia Udaondo,1 Maria Sancho-Tello,2 and F. Javier Romero2,4

1From the Department of Ophthalmology, University General Hospital of Valencia, Valencia, Spain; the 2Superior Ophthalmology Centre of the Valencian Community, Mediterranean Ophthalmology Foundation, Valencia, Spain; the 3Ophthalmology Department of the Medical School of Valencia, University of Valencia, Valencia, Spain; and the 4Department of Pharmacology Physiology and Neurotoxicology of the "Cardenal Herrera-CEU" University, Valencia, Spain.

PURPOSE. To determine the level of vascular endothelial growth factor A (VEGF-A) in aqueous humors of patients with retinitis pigmentosa (RP).

METHODS. A prospective, comparative control study. Aqueous humor was collected from 16 eyes of 16 patients with RP. The level of VEGF-A was determined with a commercially available enzyme-linked immunosorbent assay kit. The control group comprised 16 aqueous samples from 16 patients about to undergo cataract surgery and without any other ocular or systemic diseases.

RESULTS. The concentration of VEGF-A in aqueous humor was markedly lower in patients with RP than in control subjects (Mann-Whitney U test, P < 0.001). The level of VEGF-A was 94.9 ± 99.8 (mean ± SD) pg/mL in eyes with RP and 336.5 ± 116.8 pg/mL in the eyes of the control group.

CONCLUSIONS. In patients with RP, the concentration of VEGF-A in aqueous humors is lower than in non-RP subjects. The lack of angiogenic actions attributed to VEGF-A may explain some of the clinical manifestations of this disease, such as narrowing and fibrotic degeneration of retinal blood vessels.






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