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Originally published In Press as doi:10.1167/iovs.07-1620 on March 14, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:4058-4063.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-1620
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Influence of a Quantitative Trait Locus on Mouse Chromosome 19 to the Light-Adapted Electroretinogram

Alison L. Reynolds,1 Michael Danciger,2 G. Jane Farrar,1 Peter Humphries,1 and Paul F. Kenna1

1From the Smurfit Institute of Genetics, Trinity College, Dublin, Ireland; and the 2Department of Biology, Loyola Marymount University, Los Angeles, California.

PURPOSE. Both implicit time and amplitude of the cone-mediated electroretinographic (ERG) b-wave differ significantly between the C57BL/6JOlaHsd and 129S2/SvHsd inbred mouse strains. The purpose of this work was to undertake a quantitative genetics study to localize the gene or genes involved.

METHODS. Implicit time and amplitude of the a- and b-waves of the single-flash and flicker cone-mediated ERG were recorded as the quantitative traits in reciprocal backcrossed populations. A genome-wide scan was performed with 106 polymorphic markers. Map Manager (release QTXb20) was used to analyze the data and make phenotype–genotype correlations.

RESULTS. A quantitative trait locus (QTL) of major effect in controlling variation in both implicit time and amplitude of the cone-mediated ERG localized to the middle of chromosome 19.

CONCLUSIONS. Mapping of a QTL influencing both implicit time and b-wave amplitude of the light-adapted ERG represents an initial step toward identifying the gene(s) responsible for this phenotypic variation.




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[Abstract] [PDF]


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