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Originally published In Press as doi:10.1167/iovs.08-3117 on June 3, 2009
 (Investigative Ophthalmology and Visual Science. 2009;50:5247-5250.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-3117
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Glaucoma Filtration Surgery and Retinal Oxygen Saturation

Sveinn Hakon Hardarson,1,2 Maria Soffia Gottfredsdottir,1 Gisli Hreinn Halldorsson,2 Robert Arnar Karlsson,2 Jon Atli Benediktsson,3 Thor Eysteinsson,1 James M. Beach,2 Alon Harris,4 and Einar Stefansson1

From the 1Department of Ophthalmology, University of Iceland/Landspítali–University Hospital, Reykjavik, Iceland; 2Oxymap ehf., Reykjavik, Iceland; the 3Department of Electrical and Computer Engineering, University of Iceland, Reykjavik, Iceland; and the 4School of Medicine, Indiana University, Indianapolis, Indiana.

Corresponding author: Einar Stefansson, Department of Ophthalmology, Landspítali, University Hospital, Eiríksgata 37, 101 Reykjavík, Iceland; einarste{at}landspitali.is.

Purpose. Glaucoma may involve disturbances in retinal oxygenation and blood flow. The purpose of this study was to measure the effect of glaucoma filtration surgery on retinal vessel oxygen saturation.

Methods. A noninvasive spectrophotometric retinal oximeter was used to measure hemoglobin oxygen saturation in retinal arterioles and venules before and after glaucoma filtration surgery. Twenty-five consecutive patients were recruited, and 19 had adequate image quality. Fourteen underwent trabeculectomy and five glaucoma tube surgery. Twelve had primary open-angle glaucoma and seven had exfoliative glaucoma. IOP decreased from 23 ± 7 to 10 ± 4 mm Hg (mean ± SD, P = 0.0001).

Results. Oxygen saturation increased in retinal arterioles from 97% ± 4% to 99% ± 6% (n = 19; P = 0.046) after surgery and was unchanged in venules (63% ± 5% before surgery and 64% ± 6% after, P = 0.76). There were no significant changes in saturation in the fellow eyes (P > 0.60). The arteriovenous difference was 34% before and 36% after surgery (P = 0.35).

Conclusions. Glaucoma filtration surgery had almost no effect on retinal vessel oxygen saturation.






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