IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1167/iovs.08-2329 on October 3, 2008
 (Investigative Ophthalmology and Visual Science. 2009;50:1137-1144.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-2329
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
iovs.08-2329v1
50/3/1137    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fan, X.
Right arrow Articles by Yao, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fan, X.
Right arrow Articles by Yao, G.

Sex-Specific Lateralization of Contraction Anisocoria in Transient Pupillary Light Reflex

Xiaofei Fan,1 Judith H. Miles,2,3 Nicole Takahashi,2,3 and Gang Yao1

1From the Departments of Biological Engineering and 3Child Health and the 2Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri-Columbia, Columbia, Missouri.

PURPOSE. Contraction anisocoria describes a phenomenon in which the pupil of a directly illuminated eye constricts more than the pupil of the consensual (not illuminated) eye. The purpose of this study was to investigate the lateralization of contraction anisocoria in young female and male subjects.

METHODS. Infrared binocular pupillography was used to measure pupillary light reflex (PLR) in 44 healthy children (23 girls, 21 boys) from 6 to 16 years of age. Measurements were conducted in both light-adapted and dark-adapted conditions with different stimulus intensities. Relative constriction amplitude was obtained by dividing the maximal pupil area change by the initial static pupil area. Contraction anisocoria was calculated by subtracting relative constriction amplitude in the consensual eye from that of the direct eye. Values of contraction anisocoria obtained by stimulating a subject’s right or left eye were compared to determine any potential lateralization.

RESULTS. It was found that stimulating the right eye led to larger contraction anisocoria than stimulating the left eye. Such right-side lateralization of contraction anisocoria is much greater in males than in females. In addition, the effects of sex were related to the ambient light level and stimulus intensity.

CONCLUSIONS. These results provide evidence that contraction anisocoria is more laterally asymmetric in males than in females.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2009 by the Association for Research in Vision and Ophthalmology