IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1167/iovs.08-2656 on December 5, 2008
 (Investigative Ophthalmology and Visual Science. 2009;50:1814-1818.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-2656
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
iovs.08-2656v1
50/4/1814    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Qu, J.
Right arrow Articles by Washington, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Qu, J.
Right arrow Articles by Washington, I.

Coenzyme Q10 in the Human Retina

Jinfeng Qu,1,2 Yardana Kaufman,1 and Ilyas Washington1

1From the Department of Ophthalmology, Columbia University Medical Center, New York, New York; and the 2Department of Ophthalmology of Peking University, Beijing, China.

PURPOSE. To determine the concentration of coenzyme Q10 (CoQ10) in the human retina.

METHODS. Eye tissues were lyophilized and exhaustively extracted with heptane. The extracts were analyzed for CoQ10 by high-performance liquid chromatography (HPLC).

RESULTS. The average concentration of CoQ10 in the retina was 42 ± 11 nanomoles/g dry retina for donors younger than 30 years of age and 24 ± 13 nanomoles/g dry retina for donors older than 80 years of age. The average concentrations of CoQ10 in the choroid was 27 ± 16 nanomoles/g dry choroid for donors younger than 30 age and 18 ± 11 nanomoles/g dry choroid for donors older than 80.

CONCLUSIONS. CoQ10 levels in the retina can decline by approximately 40% with age. This decline may have two consequences: a decrease in antioxidant ability and a decrease in the rate of ATP synthesis in the retina and, as such, this decline may be linked to the progression of macular degeneration.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2009 by the Association for Research in Vision and Ophthalmology