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Originally published In Press as doi:10.1167/iovs.08-2845 on December 5, 2008
 (Investigative Ophthalmology and Visual Science. 2009;50:1848-1855.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-2845
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A Comparison of Macular Translocation with Patch Graft in Neovascular Age-Related Macular Degeneration

Fred K. Chen,1,2 Praveen J. Patel,1,2 Gurmit S. Uppal,1 Gary S. Rubin,1,2,3 Peter J. Coffey,2 G. William Aylward,1 and Lyndon Da Cruz1,2

1From the Moorfields Eye Hospital, London, United Kingdom; the 2Institute of Ophthalmology, University College of London, London, United Kingdom; and the 3National Institute of Health Research (NIHR) Biomedical Research Centre for Ophthalmology, London, United Kingdom.

PURPOSE. To compare the long-term outcomes of macular translocation (MT) and autologous RPE–choroid patch graft (PG) in patients with neovascular age-related macular degeneration (AMD).

METHODS. This is a retrospective review of the first 12 patients who underwent MT and the first 12 patients who underwent PG. Visual acuity (VA), contrast sensitivity (CS), clinical findings, and complications were recorded. Microperimetry and fundus imaging were reviewed. Outcome measures were the change in VA and CS over 3 years in each group and rates of complication. Microperimetry and fixation in three best cases from each group were described.

RESULTS. The two groups were matched for age and VA. Median follow-up durations were 41 (MT) and 38 (PG) months. Median VA (logMAR) was maintained in the MT group: 0.90 at baseline and 0.69 at 3 years (P = 0.09) whereas in the PG group, median VA declined from 0.87 to 1.38 at 3 years (P < 0.001). Both surgical modalities had high rates of detachment and macular edema. Although more extensive RPE damage occurred in PG, the graft resisted growth of recurrent choroidal neovascularization toward the fovea. Near normal VA was achievable by each technique but macular sensitivity and fixation stability were superior in the MT group.

CONCLUSIONS. In the present cohort, MT maintained VA for 3 years but PG did not. This outcome may be related to the differences in surgical approach, source of RPE, and choroidal perfusion. The authors recommend MT in preference to PG for treatment of patients with the second eye affected by neovascular AMD unsuitable for other treatment.




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Macular pigment and fixation after macular translocation surgery
Br J Ophthalmol, February 1, 2010; 94(2): 190 - 196.
[Abstract] [Full Text] [PDF]


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