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Originally published In Press as doi:10.1167/iovs.08-3082 on January 17, 2009
 (Investigative Ophthalmology and Visual Science. 2009;50:2040-2043.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-3082
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Distribution and Heritability of Intraocular Pressure in Chinese Children: The Guangzhou Twin Eye Study

Yingfeng Zheng,1 Fan Xiang,1 Wenyong Huang,1 Guofu Huang,1 Qiuxia Yin,1 and Mingguang He1,2

1From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People’s Republic of China; and 2UCL Institute of Ophthalmology, London, United Kingdom.

PURPOSE. To assess the distribution and heritability of intraocular pressure (IOP) in Chinese children.

METHODS. Twins aged 8 to 16 years were recruited from the Guangzhou Twin Registry. IOP was measured in each twin and co-twin together, with a handheld tonometer by the same operator. Zygosity was determined based on genotyping with 16 polymorphic markers in all same-sex twin pairs. Heritability was estimated with a univariate variance component model.

RESULTS. Four hundred seventy-three twin pairs (309 monozygotic [MZ] and 164 dizygotic [DZ] twins) were available for data analyses. The mean IOP was 14.2 (SD 2.3) mm Hg. Neither age nor sex was correlated with IOP. Phenotypic correlation was 0.68 (95% confidence interval [CI], 0.62–0.74) in MZ twins and 0.40 (95% CI, 0.26–0.52) in DZ twins. A genetic model involving additive genetic and unique environmental effects was the best fit. Heritability was estimated as 66.5% (95% CI, 60.6%–71.6%).

CONCLUSIONS. IOP is not correlated with age and sex in young children. Similar to the European population, the variation of IOP in healthy Chinese children is mainly attributable to additive genetic effects.






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