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Originally published In Press as doi:10.1167/iovs.08-2582 on January 31, 2009
 (Investigative Ophthalmology and Visual Science. 2009;50:2626-2631.)
© 2009 by The Association for Research in Vision and Ophthalmology, Inc.
doi:10.1167/iovs.08-2582
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Variation of Angle Parameters in Asians: An Anterior Segment Optical Coherence Tomography Study in a Population of Singapore Malays

Nishani Amerasinghe,1 Paul J. Foster,2 Tien Yin Wong,1,3,4 Hla Myint Htoon,4 Mingguang He,5 Sunny Y. Shen,1 Han T. Aung,4 Seang-Mei Saw,4,6 and Tin Aung1,4,6

1From the Singapore National Eye Centre, Singapore; the 2National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom; the 3Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; the 4Singapore Eye Research Institute, Singapore; the 5Zhongshan Ophthalmic Center, Guangzhou, China; and the 6Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

PURPOSE. To assess variations in angle parameters using anterior segment optical coherence tomography (AS-OCT) and to investigate demographic, ocular and systemic associations of angle width.

METHODS. This was a substudy of a population based, cross-sectional survey of 3280 (78.7% response rate) Malay people aged 40 to 80 years in Singapore. All participants underwent a standardized interview and ocular and systemic examination. AS-OCT was performed on 291 consecutive patients in standardized dark conditions. Angle opening distance (AOD-500) and trabecular–iris space area (TISA-500) 500 µm from the scleral spur were determined for the nasal and temporal angles. Anterior chamber depth (ACD) was also measured.

RESULTS. AS-OCT measurements were analyzed in 239 (82.1%) right eyes. Mean AOD 500 was smaller in women than in men, both nasally (0.255 vs. 0.293 mm, P = 0.026) and temporally (0.245 vs. 0.286 mm, P = 0.023). Mean TISA-500 was smaller in women in the nasal quadrant only (0.104 vs. 0.117 mm, P = 0.035). Mean ACD was smaller in women than in men (2.71 vs. 2.87 mm, P = 0.001). Multiple linear regression showed that axial length and ACD were significantly associated with AOD-500 and TISA-500 both nasally (adjusted R2 = 0.34 for AOD-500 and 0.20 for TISA-500) and temporally (adjusted R2 = 0.35 for AOD-500 and 0.24 for TISA-500). Body mass index, HbA1c, systolic blood pressure, intraocular pressure, cup-to-disc ratio, and central corneal thickness were not significantly associated with AOD-500, TISA-500, or ACD.

CONCLUSIONS. In this Malay population, angle width measured by AS-OCT was smaller in women than in men, and in eyes with shorter axial length and shallower ACD.






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